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Los efectos del 5-HT en la disfunción endotelial vascular en pacientes con trastorno de pánico
Yueqi Feng1, Xixi Li1, Zijia Li2
1Department of Geriatrics, The First Hospital of China Medical University, Shenyang, Liaoning, China.
Frontiers in cardiovascular medicine
|September 5, 2025
Resumen
Esta revisión explora cómo la serotonina (5-HT) impacta el trastorno de pánico y las enfermedades cardiovasculares, destacando su papel en la función vascular y las posibles implicaciones del tratamiento para los pacientes.
Área de la Ciencia:
- La neurociencia
- Cardiología
- La psiquiatría
Sus antecedentes:
- El trastorno de pánico (TP) y las enfermedades cardiovasculares (ECV) con frecuencia ocurren al mismo tiempo, compartiendo síntomas superpuestos.
- Los mecanismos subyacentes que vinculan la EP y la ECV, en particular la 5-hidroxitriptamina (5-HT), no se comprenden completamente.
- 5-HT juega un papel en la etiología de la EP e influye en el tono vascular y la función plaquetaria.
Objetivo del estudio:
- Revisar la comprensión actual del papel de 5-HT en la intersección de la EP y la disfunción vascular.
- Para sintetizar los hallazgos recientes sobre el impacto de 5-HT en el tono vascular, la producción de óxido nítrico y la agregación plaquetaria.
- Examinar las posibles implicaciones terapéuticas de la orientación del sistema 5-HT para la enfermedad de Parkinson y las enfermedades cardiovasculares comórbidas.
Principales métodos:
- Revisión de la literatura que sintetiza la investigación actual sobre el 5-HT, la EP y la función vascular.
- Análisis de los mecanismos de acción de 5-HT sobre el tono vascular a través de los receptores 5-HT1B y 5-HT2A.
- Examen de la vía de señalización PI3K/Akt/eNOS en la función endotelial mediada por 5-HT.
Principales resultados:
- El 5-HT modula el tono vascular y la producción de óxido nítrico, afectando la respuesta vasomotriz.
- El sistema 5-HT influye en la activación y agregación plaquetaria, contribuyendo al riesgo de ECV.
- Los inhibidores selectivos de la recaptación de serotonina (ISRS, por sus siglas en inglés) pueden mejorar la función endotelial vascular, pero sus efectos sobre las enfermedades cardiovasculares son objeto de debate.
Conclusiones:
- La compleja interacción entre la PD, el 5-HT y la función endotelial vascular requiere más investigación.
- La comprensión de estos mecanismos podría conducir a mejores tratamientos para la EP y las ECV asociadas.
- Dirigirse al sistema 5-HT puede ofrecer nuevas estrategias terapéuticas para afecciones comórbidas, mejorando los resultados de los pacientes.
Palabras clave:
El 5-HTEnfermedades cardiovascularestrastorno de pánicoInhibidores selectivos de la recaptación de serotoninavías de señalizaciónFunción endotelial vascularMás Videos Relacionados
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