Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

154
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
154
Renal Failure: Dose Adjustments01:11

Renal Failure: Dose Adjustments

151
In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
151
Factors Affecting Renal Clearance: Drug Distribution and Drug Interactions01:09

Factors Affecting Renal Clearance: Drug Distribution and Drug Interactions

223
Renal clearance plays a pivotal role in drug elimination from the body and can be influenced by drug distribution and interactions. Understanding these factors is crucial in pharmacology as they impact the effectiveness and duration of drug therapy.
One important factor is the relationship between renal clearance and the apparent volume of distribution. Renal clearance tends to be inversely proportional to the apparent volume of distribution. Drugs with an extensive distribution volume or those...
223
Renal Drug Clearance: Comparison Between Renal Excretion Methods01:08

Renal Drug Clearance: Comparison Between Renal Excretion Methods

267
Renal clearance is a critical parameter encompassing kidney filtration, secretion, and reabsorption processes. It is calculated using a specific equation to determine the rate at which the kidneys clear a drug.
Renal clearance is often associated with the renal glomerular filtration rate (GFR), which represents the rate at which plasma is filtered through the glomeruli in the kidney. When drug reabsorption is minimal and there is no active secretion, renal clearance is closely related to the...
267
Renal Drug Clearance: Overview01:06

Renal Drug Clearance: Overview

321
Renal clearance is a crucial parameter in pharmacokinetics that quantifies the rate at which the kidneys excrete a drug. It represents a constant fraction of the central volume of distribution containing the drug that the kidney eliminates per unit of time.
Renal clearance can be calculated using different methods. One approach is to divide the urinary drug excretion rate by the plasma drug concentration. This method directly measures renal clearance, indicating the kidneys' efficiency in...
321
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

57
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
57

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Transitions of care following acute kidney injury: a systems-based analysis.

BMC nephrology·2026
Same author

Comparing paper Letters in addition to Emailed Audit and feedback in Refining Asthma treatment to Improve clinical and environmental Results in primary care through a cluster randomised controlled trial: the CLEAR AIR study.

BMJ open respiratory research·2026
Same author

Acceptability, appropriateness and costs of a tailored implementation strategy for the national falls prevention recommendations in Norwegian municipalities-a process evaluation of the FALLPREVENT trial.

Age and ageing·2026
Same author

Defining Patient and Public Involvement and Engagement Tasks in Health Data Research: A Consensus Study.

Health expectations : an international journal of public participation in health care and health policy·2026
Same author

Experience-based co-design informed development of a toolbox to help optimise primary care support during transition from children's hospice care: HOPSCOTCH study protocol.

BMJ open·2025
Same author

Tailored implementation of national recommendations on falls prevention amongst older adults in municipalities in Norway-FALLPREVENT-a hybrid type 3 cluster-randomised trial.

Age and ageing·2025

Video Experimental Relacionado

Updated: Sep 9, 2025

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform
07:13

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform

Published on: April 12, 2021

4.5K

El aclaramiento de la creatinina, la función renal reducida y la optimización de la seguridad de la prescripción a

Su I Wood1, Robbie Foy1, Paul Carder2

  • 1Division of Primary Care, Palliative Care and Public Health, Leeds Institute of Health Sciences, University of Leeds, Leeds LS2 9LN, United Kingdom.

Family practice
|September 5, 2025
PubMed
Resumen
Este resumen es generado por máquina.

La retroalimentación de rendimiento mejoró el cálculo y la codificación del aclaramiento de la creatinina (CrCl) en adultos mayores, pero se necesita más apoyo del sistema para reducir los errores de medicación en la función renal reducida.

Palabras clave:
Estudios de viabilidadPráctica generalEstudios longitudinalesla prescripciónInvestigación cualitativacalidad y seguridad

Más Videos Relacionados

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
05:34

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

833
Direct Drug Delivery to Kidney via the Renal Artery
11:18

Direct Drug Delivery to Kidney via the Renal Artery

Published on: April 17, 2021

7.5K

Videos de Experimentos Relacionados

Last Updated: Sep 9, 2025

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform
07:13

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform

Published on: April 12, 2021

4.5K
5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
05:34

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

833
Direct Drug Delivery to Kidney via the Renal Artery
11:18

Direct Drug Delivery to Kidney via the Renal Artery

Published on: April 17, 2021

7.5K

Área de la Ciencia:

  • Medicina para la edad avanzada
  • Farmacia clínica
  • Investigación en servicios de salud

Sus antecedentes:

  • La función renal disminuye naturalmente con la edad, elevando el riesgo de eventos adversos debido a los niveles más altos de medicamentos.
  • La prescripción inadecuada es común en pacientes ancianos con disminución del aclaramiento de la creatinina (CrCl).

Objetivo del estudio:

  • Evaluar la viabilidad y aceptabilidad de las intervenciones de retroalimentación de rendimiento.
  • Mejorar las prácticas de cálculo y codificación del CrCl.
  • Para reducir la prescripción potencialmente inadecuada en adultos mayores.

Principales métodos:

  • Un estudio de métodos mixtos que incluye retroalimentación de rendimiento basada en la evidencia sobre la codificación y prescripción de CrCl en siete prácticas generales del Reino Unido.
  • Recopilación de datos en tres momentos, con evaluaciones previas y posteriores a la intervención.
  • La etnografía institucional incluye observaciones y entrevistas semiestructuradas con médicos de atención primaria.

Principales resultados:

  • La codificación media de CrCl en pacientes de 75 años o más aumentó del 46% al 50,4%.
  • Se observó una reducción en el número de pacientes con prescripción inadecuada asociada con CrCl.
  • Los médicos encontraron la retroalimentación atractiva y flexible, aunque persistieron los desafíos en el cálculo de CrCl y el retiro de medicamentos.

Conclusiones:

  • La retroalimentación del rendimiento puede impulsar mejoras en la prescripción para la función renal reducida, pero requiere apoyo suplementario.
  • El cálculo y la codificación sistematizados del CrCl son cruciales para mejorar la seguridad del paciente a través de un mejor apoyo a la toma de decisiones.
  • Se considera factible y aceptable una evaluación de la eficacia a gran escala.