Video Experimental Relacionado

Updated: Sep 9, 2025

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform
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Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform

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Un diseño robusto de optimización de dosis bayesiana con relleno y aleatorización para ensayos clínicos de fase I/II

Yingjie Qiu1,2, Mingyue Li1

  • 1Peter O'Donnell Jr. School of Public Health, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Statistical methods in medical research
|September 5, 2025
PubMed
Resumen

Las cohortes de relleno en ensayos de fase I mejoran la seguridad y la eficiencia de los nuevos medicamentos contra el cáncer. Este diseño bayesiano mejora la selección de dosis óptima y reduce la exposición del paciente a tratamientos ineficaces.

Palabras clave:
El rellenodiseños adaptativosOptimización de la dosisproyecto optimusCompromiso entre el riesgo y los beneficios

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