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Updated: Sep 8, 2025
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Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
Published on: August 28, 2015
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Caracterización fisicoquímica de los tensioactivos no iónicos a base de polioxietileno (POE) en entornos micelares
Virendra Prajapati1, Yashika Tomar2, Gautam Singhvi2
1Department of Chemistry, Sardar Vallabhbhai National Institute of Technology (SVNIT), Ichchhanath Dumas Road, Keval Chowk, Surat-395007, Gujarat, India. ketankuperkar@gmail.com.
Physical chemistry chemical physics : PCCP
|September 5, 2025
Resumen
Este estudio explora la formación de micelas a nanoescala utilizando Soluplus® y otros tensioactivos, revelando efectos sinérgicos que mejoran la solubilización del fármaco y la liberación controlada. La investigación pone de relieve el Soluplus®
Área de la Ciencia:
- Ciencias de las superficies y coloides
- Ciencias de los materiales
- Ciencias farmacéuticas
Sus antecedentes:
- Los copolímeros de injerto anfifílico como Soluplus® son cruciales en la formulación de medicamentos poco solubles.
- La comprensión del comportamiento micelar en sistemas de surfactantes individuales y mixtos es clave para las aplicaciones de administración de fármacos.
- Los tensioactivos no iónicos a base de polioxietileno (POE) presentan diversas propiedades de solución influenciadas por la concentración y la temperatura.
Objetivo del estudio:
- Investigar la formación micelar a nanoescala y el comportamiento de la solución de Soluplus® en combinación con varios tensioactivos no iónicos basados en POE.
- Caracterizar el impacto de la mezcla de surfactantes en la morfología de las micelas, la estabilidad y la capacidad de solubilización de fármacos.
- Evaluar la cinética de liberación de fármacos in vitro de la quercetina (QCT) de estos sistemas a nanoescala.
Principales métodos:
- Medidas reológicas para determinar la viscosidad y las propiedades viscoelásticas de la solución.
- Diseminación dinámica de luz (DLS) y dispersión de neutrones de ángulo pequeño (SANS) para el análisis del tamaño y la forma de la micela.
- Espectroscopia UV-visible para cuantificar la solubilización de la quercetina (QCT).
Principales resultados:
- Soluplus® forma grandes micelas esféricas, mientras que P123 exhibe gelación termoreversible y transiciones morfológicas.
- Los sistemas mixtos Soluplus® demuestran interacciones sinérgicas, aumentando significativamente los puntos de nube y mejorando la solubilización de QCT.
- El modelo de Higuchi describe mejor la liberación de fármacos in vitro, lo que indica un mecanismo controlado por difusión.
Conclusiones:
- Los sistemas micelares mixtos basados en Soluplus® ofrecen una solubilización superior y una liberación controlada de fármacos hidrofóbicos como QCT.
- Las interacciones sinérgicas en mezclas específicas de Soluplus® son ventajosas para el desarrollo de formulaciones farmacéuticas.
- Estos ensamblajes a nanoescala proporcionan una plataforma prometedora para mejorar la entrega de ingredientes farmacéuticos activos hidrofóbicos.
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