Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

3.1K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
3.1K
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

2.9K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
2.9K
Bone Remodeling01:40

Bone Remodeling

38.5K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
38.5K
Bone Formation by Endochondral Ossification01:24

Bone Formation by Endochondral Ossification

5.4K
Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...
5.4K

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Nutritional Support for Treatment Continuity and Survival in Advanced Gastric Cancer: A Propensity Score-matched Study.

In vivo (Athens, Greece)·2026
Same author

Bee larvae ameliorate andropause-like symptoms via a hormone-independent, antioxidant mechanism.

Frontiers in physiology·2026
Same author

Clinical Outcomes in Advanced Gastric Cancer Among Patients Aged ≥80 Years Treated With Chemotherapy.

Anticancer research·2026
Same author

Pyroxylin shortens the resting stage of the hair cycle in mice.

Scientific reports·2026
Same author

Real-world platinum selection in immune checkpoint inhibitor-based therapy for recurrent or metastatic head and neck cancer: an exploratory multi-institutional retrospective study.

Scientific reports·2026
Same author

Fluid shear stress activates c-Src and promotes RANKL localization in the plasma membrane in osteoblast-like MC3T3-E1 cells.

BBA advances·2026

Video Experimental Relacionado

Updated: Sep 8, 2025

Isolation of Mesenchymal Stem Cells from Human Alveolar Periosteum and Effects of Vitamin D on Osteogenic Activity of Periosteum-derived Cells
06:47

Isolation of Mesenchymal Stem Cells from Human Alveolar Periosteum and Effects of Vitamin D on Osteogenic Activity of Periosteum-derived Cells

Published on: May 4, 2018

9.5K

El ácido sebásico promueve la diferenciación de los osteoblastos

Thira Rojasawasthien1,2, Takumi Ito3, Hideto Okamoto4

  • 1Division of Biochemistry, Kyushu Dental University, Kitakyushu, Japan.

Bioscience, biotechnology, and biochemistry
|September 5, 2025
PubMed
Resumen

Se estudiaron los metabolitos de la jalea real, el ácido sebásico (SA) y el ácido 2-decenoico (2DA), para la salud ósea. El ácido sebásico promovió significativamente la diferenciación de los osteoblastos y la expresión del gen marcador óseo, a diferencia del 2DA.

Palabras clave:
Ácido 2-decenedioico (2DA)OsteoblastogénesisLa jalea realy el ácido 10-hidroxidecanoico (10HDAA)y ácidos sébacicos (SA)Ácido graso

Más Videos Relacionados

Application of Retinoic Acid to Obtain Osteocytes Cultures from Primary Mouse Osteoblasts
07:13

Application of Retinoic Acid to Obtain Osteocytes Cultures from Primary Mouse Osteoblasts

Published on: May 13, 2014

13.5K
Differentiation and Characterization of Osteoclasts from Human Induced Pluripotent Stem Cells
10:52

Differentiation and Characterization of Osteoclasts from Human Induced Pluripotent Stem Cells

Published on: March 22, 2024

1.8K

Videos de Experimentos Relacionados

Last Updated: Sep 8, 2025

Isolation of Mesenchymal Stem Cells from Human Alveolar Periosteum and Effects of Vitamin D on Osteogenic Activity of Periosteum-derived Cells
06:47

Isolation of Mesenchymal Stem Cells from Human Alveolar Periosteum and Effects of Vitamin D on Osteogenic Activity of Periosteum-derived Cells

Published on: May 4, 2018

9.5K
Application of Retinoic Acid to Obtain Osteocytes Cultures from Primary Mouse Osteoblasts
07:13

Application of Retinoic Acid to Obtain Osteocytes Cultures from Primary Mouse Osteoblasts

Published on: May 13, 2014

13.5K
Differentiation and Characterization of Osteoclasts from Human Induced Pluripotent Stem Cells
10:52

Differentiation and Characterization of Osteoclasts from Human Induced Pluripotent Stem Cells

Published on: March 22, 2024

1.8K

Área de la Ciencia:

  • La bioquímica
  • Biología ósea
  • Productos nutracéuticos

Sus antecedentes:

  • La jalea real contiene ácidos grasos como el ácido 10-hidroxi-2-decenoico (10H2DA) y el ácido 10-hidroxi-decanoico (10HDAA).
  • Estos ácidos grasos RJ se metabolizan en ácido 2-decenoico (2DA) y ácido sebásico (SA) en el hígado.
  • El papel de estos metabolitos en el metabolismo óseo requiere más investigación.

Objetivo del estudio:

  • Investigar los efectos de 2DA y SA en la diferenciación de los osteoblastos.
  • Comprender las contribuciones específicas de los metabolitos de RJ a la salud ósea.

Principales métodos:

  • Se utilizaron células de linaje osteoblástico para estudios in vitro.
  • Se administró 2DA y SA a cultivos celulares.
  • Se midió la expresión génica del marcador osteoblástico y la actividad de la fosfatasa alcalina.

Principales resultados:

  • El ácido sebásico (SA) aumentó significativamente los genes marcadores clave de los osteoblastos.
  • El tratamiento con SA aumentó la actividad de la fosfatasa alcalina, lo que indica una mayor diferenciación.
  • El ácido 2-decenoico (2DA) no mostró ningún efecto significativo en la diferenciación de los osteoblastos.

Conclusiones:

  • El ácido sebásico, un metabolito de la jalea real, promueve la diferenciación de los osteoblastos.
  • La SA puede desempeñar un papel crucial en los beneficios del metabolismo óseo atribuidos a la jalea real.
  • Se necesitan más investigaciones sobre los mecanismos de la SA en la salud ósea.