Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Exercise and Cardiac Output01:17

Exercise and Cardiac Output

1.3K
Regular physical activity is essential for maintaining cardiovascular health, with aerobic exercises being particularly effective. According to the American Heart Association, 150 minutes of moderate to intense aerobic exercise per week is recommended for a healthy heart. Aerobic activities may include brisk walking, running, bicycling, cross-country skiing, and swimming, ideally performed three to five times per week.
Sustained exercise increases the muscles' oxygen demand, which can be...
1.3K
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

21
Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
21
Pathophysiology of Cardiac Performance01:29

Pathophysiology of Cardiac Performance

798
Typical heart performance is influenced by heart rate, rhythm, myocardial contraction, and metabolism or blood flow. The cardiac muscle exhibits distinct electrophysiological features, including pacemaker activity and calcium channel control, which play a vital role in the heart's response to various drugs. The autonomic nervous system, comprising the sympathetic and parasympathetic branches, regulates heart rate. Sympathetic activation increases heart rate, while parasympathetic activation...
798
Cardiac Output I:Effect of Heart Rate on Cardiac Output01:19

Cardiac Output I:Effect of Heart Rate on Cardiac Output

1.2K
Cardiac Output
Cardiac output (CO) refers to the total amount of blood ejected by one of the ventricles in liters per minute (L/min). In a resting adult, CO ranges from 5 to 6 L/min, adjusting according to the body's metabolic requirements.
Effect of Heart Rate on Cardiac Output
Cardiac output adapts to metabolic demands during stress, physical activity, or illness. The autonomic nervous system regulates heart rate via the sinoatrial node. The parasympathetic nervous system decreases heart...
1.2K
Imbalances in Cardiac Output01:26

Imbalances in Cardiac Output

1.5K
The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
1.5K
Heart Failure Drugs: Inotropic Agents01:26

Heart Failure Drugs: Inotropic Agents

716
Positive inotropic agents are commonly used as the first line of treatment for heart failure. One such agent is digoxin, derived from the genus Digitalis, which has been known for centuries but effectively utilized since 1785. However, these cardiac glycosides can have potentially toxic effects due to their mechanism of action, which involves inhibiting Na+/K+-ATPase and increasing contractility. Digoxin is absorbed orally and distributed in various tissues, including the CNS. It has a long...
716

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Mitochondrial peptide MOTS-c suppresses systemic and cardiac inflammasome activation in a diabetic rat model.

Experimental physiology·2026
Same author

Substrate-specific mitochondrial dysfunction and metabolomic profiles in type 2 diabetic rat hearts.

Experimental physiology·2026
Same author

Mitochondrial respiration and hydrogen peroxide production rate in right atrial tissues from obese diabetic patients.

Experimental physiology·2026
Same author

Type 2 diabetes disrupts T-tubule and RyR2 organization in male but not in female rat ventricular muscle.

American journal of physiology. Heart and circulatory physiology·2026
Same author

The Absence of Collagen VI Reduces Systolic Function but Paradoxically Increases Ca<sup>2+</sup> Release in the Rat Heart.

Acta physiologica (Oxford, England)·2025
Same author

Distinct profiles of mitochondrial bioenergetics and redox balance in left atrial and ventricular myocardium in the healthy rat heart.

Experimental physiology·2025
Same journal

Smooth muscle cell polycystin 1 (PKD1) is dispensable for physiological regulation of arterial contractility.

The Journal of physiology·2026
Same journal

Protein synthesis in collagenous and non-collagenous fractions of human patellar tendon: Influence of tendinopathy and short-term exercise.

The Journal of physiology·2026
Same journal

Who are you, ketamine? Good, evil, or dose- and context-dependent?

The Journal of physiology·2026
Same journal

Nuances in explaining the blunted erythropoietic response at altitude following recombinant human erythropoietin treatment at sea level.

The Journal of physiology·2026
Same journal

Sex-dependent responses to glucagon agonist therapies in obesity: Mechanistic insights and broader pharmacological implications.

The Journal of physiology·2026
Same journal

Brain sparing in fetal growth restriction: The double-edged sword of fetal hypoxaemia.

The Journal of physiology·2026
Ver todos los artículos relacionados

Video Experimental Relacionado

Updated: Sep 8, 2025

Simultaneous Electrical and Mechanical Stimulation to Enhance Cells' Cardiomyogenic Potential
07:41

Simultaneous Electrical and Mechanical Stimulation to Enhance Cells' Cardiomyogenic Potential

Published on: January 18, 2019

7.6K

Danicamtiv aumenta la eficiencia mecánica del corazón

Trent Meehan1, Toan Pham1, Kenneth Tran1

  • 1Auckland Bioengineering Institute, The University of Auckland, Auckland, New Zealand.

The Journal of physiology
|September 5, 2025
PubMed
Resumen
Este resumen es generado por máquina.

Danicamtiv, un activador cardíaco de la miosina, mejora la eficiencia del músculo cardíaco al aumentar la fuerza producida y el trabajo realizado sin aumentar el uso de energía para el ciclo del calcio. Este estudio revela su doble beneficio para la mecánica cardíaca y la energética.

Palabras clave:
Energía cardíacaeficiencia del puente transversalel calorActivador de la miosinacontracción del bucle de trabajo

Más Videos Relacionados

Testing the Efficacy of Pharmacological Agents in a Pericardial Target Delivery Model in the Swine
10:05

Testing the Efficacy of Pharmacological Agents in a Pericardial Target Delivery Model in the Swine

Published on: July 7, 2016

8.4K
Mechanical Control of Relaxation Using Intact Cardiac Trabeculae
07:51

Mechanical Control of Relaxation Using Intact Cardiac Trabeculae

Published on: February 17, 2023

1.3K

Videos de Experimentos Relacionados

Last Updated: Sep 8, 2025

Simultaneous Electrical and Mechanical Stimulation to Enhance Cells' Cardiomyogenic Potential
07:41

Simultaneous Electrical and Mechanical Stimulation to Enhance Cells' Cardiomyogenic Potential

Published on: January 18, 2019

7.6K
Testing the Efficacy of Pharmacological Agents in a Pericardial Target Delivery Model in the Swine
10:05

Testing the Efficacy of Pharmacological Agents in a Pericardial Target Delivery Model in the Swine

Published on: July 7, 2016

8.4K
Mechanical Control of Relaxation Using Intact Cardiac Trabeculae
07:51

Mechanical Control of Relaxation Using Intact Cardiac Trabeculae

Published on: February 17, 2023

1.3K

Área de la Ciencia:

  • Fisiología cardiovascular
  • Biofísica de la contracción muscular
  • Energía cardíaca

Sus antecedentes:

  • Danicamtiv es un nuevo activador de miosina específico para el corazón.
  • Está siendo investigado en ensayos preclínicos y clínicos para mejorar la función cardíaca.

Objetivo del estudio:

  • Para evaluar los efectos de danicamtiv en la energía cardíaca.
  • Para aclarar los mecanismos detrás del impacto de danicamtiv en la fuerza y la eficiencia del miocardio.

Principales métodos:

  • Se utilizaron trabéculas ventriculares aisladas en ratas para estudios in vitro.
  • La producción de calor muscular se midió durante las contracciones isométricas y de bucle de trabajo.
  • Los trabéculas fueron expuestos a danicamtiv (5 μM) para cuantificar sus efectos sobre la fuerza, la producción de calor y la eficiencia.

Principales resultados:

  • Danicamtiv aumentó la fuerza de contracción, el calor muscular y el calor del puente cruzado.
  • Ha disminuido la contracción isométrica y acortado la cinética.
  • La eficiencia mecánica se mejoró debido a un mayor aumento en la producción de trabajo que en la producción de calor, sin efecto sobre la energía del ciclo de Ca2+.

Conclusiones:

  • Danicamtiv mejora la eficiencia mecánica cardíaca optimizando la relación entre la generación de fuerza y el gasto energético.
  • Su mecanismo consiste en mejorar las interacciones de la actomiosina sin aumentar el costo energético del manejo del calcio.
  • Danicamtiv es prometedor como agente inotrópico con beneficios mecánicos y energéticos para el corazón.