Video Experimental Relacionado
Updated: May 26, 2026
19:15
Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
Published on: August 25, 2014
86.3K
El volumen estriado neonatal está asociado con anhedonia infantil
Melissa Nevarez-Brewster1, Catherine H Demers2, Jessica L Irwin3
1University of Denver, Department of Psychology, United States of America.
Journal of affective disorders
|September 5, 2025
Resumen
El volumen estriatal neonatal, específicamente en el núcleo accumbens y el putamen, predice comportamientos anhedónicos posteriores en los bebés. Esta investigación identifica los primeros marcadores neuroanatómicos para el riesgo de anhedonia.
Área de la Ciencia:
- Neurociencia del desarrollo
- Psicología clínica
- Imágenes neurológicas
Sus antecedentes:
- La anhedonia es un factor de riesgo transdiagnóstico para la psicopatología, cada vez más reconocido en la infancia y la primera infancia.
- La variabilidad estructural estriatal está vinculada a la anhedonia, pero las asociaciones prospectivas desde la infancia no se estudian.
- Pocos estudios han examinado si la neuroanatomía neonatal predice comportamientos anhedónicos posteriores.
Objetivo del estudio:
- Investigar si los marcadores neuroanatómicos de riesgo de anhedonia son detectables en los recién nacidos.
- Para determinar si el volumen estriatal neonatal predice el comportamiento anhedónico infantil a los seis meses.
- Establecer marcadores predictivos tempranos para la vulnerabilidad de la anhedonia.
Principales métodos:
- Estudio longitudinal de cohorte de 89 recién nacidos (Proyecto Cuidado).
- Volúmenes estriados neonatales (núcleo accumbens, putamen, caudado) evaluados mediante resonancia magnética estructural.
- Comportamientos anedónicos del lactante medidos a los seis meses utilizando el Índice de Procesamiento Hedónico/Anhedónico del lactante (HAPI-Infant).
Principales resultados:
- Un mayor volumen de núcleo accumbens neonatal predijo un aumento de los comportamientos anhedónicos a los seis meses.
- Un mayor volumen de putamen neonatal también predijo un aumento de los comportamientos anhedónicos a los seis meses.
- Estas asociaciones se mantuvieron significativas después de controlar las covariables relevantes.
Conclusiones:
- El volumen estriado neonatal está asociado con anhedonia infantil.
- Este estudio proporciona la primera evidencia de marcadores de vulnerabilidad detectables para la anhedonia en los recién nacidos.
- La neuroimagen temprana puede identificar a los bebés en riesgo de desarrollar anhedonia.
Más Videos Relacionados
19:57The Use of Trace Eyeblink Classical Conditioning to Assess Hippocampal Dysfunction in a Rat Model of Fetal Alcohol Spectrum Disorders
Published on: August 5, 2017
8.5K
06:09Semi-Quantitative Determination of Dopaminergic Neuron Density in the Substantia Nigra of Rodent Models using Automated Image Analysis
Published on: February 2, 2021
4.6K
Videos de Conceptos Relacionados
01:11Normal Distribution
The normal, a continuous distribution, is the most important of all the distributions. Its graph is a bell-shaped symmetrical curve, which is observed in almost all disciplines. Some of these include psychology, business, economics, the sciences, nursing, and, of course, mathematics. Some instructors may use the normal distribution to help determine students’ grades. Most IQ scores are normally distributed. Often real-estate prices fit a normal distribution. The normal distribution is extremely...
01:17z Scores and Area Under the Curve
z scores are the standardized values obtained after converting a normal distribution into a standard normal distribution. A z score is measured in units of the standard deviation. The z score tells you how many standard deviations the value x is above (to the right of) or below (to the left of) the mean, μ. Values of x that are larger than the mean have positive z scores, and values of x that are smaller than the mean have negative z scores. If x equals the mean, then x has a z score of zero.
01:07Teratogenicity
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
01:29Drug Dosing: Infants and Children
Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
01:30Development of Human Microbiota
The human microbiota begins developing at birth and undergoes continual change as we age. Infancy marks a critical period of microbial sensitivity, offering a “window of opportunity” during which beneficial microbes help mature the immune system. By age three, children typically develop a more stable and diverse microbial community. Newborns acquire microbes from their immediate environment; vaginal delivery favors maternal vaginal microbes, while cesarean births favor microbes from the skin...
01:28Development of the Oral Microbiota
The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...