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Asociación entre los niveles séricos de metabolitos de vitamina D y la función cognitiva en adultos mayores que viven
Cai Yu1, Minae Ide1, Taiki Sugimoto2
1Department of Nutrition, Graduate School of Human Life and Ecology, Osaka Metropolitan University, 2-1-132, Osaka-shi, Osaka 536-8525, JAPAN.
Clinical nutrition ESPEN
|September 5, 2025
Resumen
Los metabolitos de la vitamina D más allá del total de 25 ((OH) D ofrecen nuevos conocimientos sobre la salud cognitiva. Los metabolitos y ratios específicos muestran asociaciones dependientes del sexo con la función cognitiva y el riesgo de enfermedad de Alzheimer.
Área de la Ciencia:
- Neurociencia y Endocrinología
- Bioquímica del metabolismo de la vitamina D
Sus antecedentes:
- La deficiencia de vitamina D está relacionada con el deterioro cognitivo y la enfermedad de Alzheimer (EA), pero los hallazgos son inconsistentes.
- El total de 25-hidroxivitamina D [25(OH) D] puede no reflejar completamente la función de la vitamina D; otros metabolitos como la 24,25-dihidroxivitamina D3 [24,25(OH) 2D3] y la 3-epímero-25-hidroxivitamina D3 [3-epi-25(OH) D3] pueden ser más informativos.
Objetivo del estudio:
- Investigar la asociación entre las concentraciones séricas de metabolitos de la vitamina D y la función cognitiva en adultos mayores.
- Explorar las posibles diferencias basadas en el sexo en estas asociaciones.
Principales métodos:
- Estudio transversal de 289 adultos (65-85 años) con EA, deterioro cognitivo leve (MCI) o cognitivamente normal (CN).
- Función cognitiva evaluada mediante el examen del estado mental en miniatura (MMSE).
- Las concentraciones séricas de 25 ((OH) D3, 25 ((OH) D2, 24,25 ((OH) 2D3, 3-epi-25 ((OH) D3, y 1,25-dihidroxivitamina D3 [1,25 ((OH) 2D3] se miden mediante el método LC-MS/MS. Se calcula el índice de metabolitos de la vitamina D.
Principales resultados:
- En los hombres, el 3-epi-25 ((OH) D3) y el 24,25 ((OH) 2D3 se relacionaron con puntuaciones MMSE más bajas y un mayor riesgo de EA.
- En las mujeres, la VMR se asoció con puntuaciones más altas de MMSE y un menor riesgo de EA, mientras que 1,25 ((OH) 2D3 se relacionó con un mayor riesgo de EA.
- Se observaron diferencias basadas en el sexo en las asociaciones de los metabolitos de vitamina D con la cognición.
Conclusiones:
- Las diferencias específicas por sexo en las asociaciones de cognición de vitamina D pueden estar influenciadas por factores hormonales.
- Los metabolitos como 1,25 ((OH) 2D3), VMR y 3-epi-25 ((OH) D3 pueden ser indicadores más sensibles de la salud cognitiva que el total de 25 ((OH) D.
Palabras clave:
Las demás sustancias no incluidas en el anexo I, parte B, del Reglamento (CE) n.o 396/2005.En el caso de las vitaminas y sus derivados, se utilizarán las siguientes sustancias:3-epímero-25-hidroxivitamina D ((3)) [3-epi-25 ((OH) D ((3)) ]Las funciones cognitivasEl índice metabólico de la vitamina D (RMV)Más Videos Relacionados
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