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Demencia con cuerpos de Lewy y disfunción del sueño
Jakub Radziwon1, Jarosław Sławek1
1Department of Neurology and Stroke, St. Adalbert Hospital, Gdańsk, Poland; Division of Neurological and Psychiatric Nursing, Faculty of Health Sciences, Medical University of Gdańsk, Dębinki 7, 80-211 Gdańsk, Poland.
Sleep medicine clinics
|September 5, 2025
Resumen
La demencia con cuerpos de Lewy interrumpe las redes del sueño, causando problemas comunes como el trastorno del comportamiento del sueño REM y la hipersomnia. Se necesita más investigación para confirmar la eficacia y la seguridad de los tratamientos disponibles para estos trastornos del sueño.
Área de la Ciencia:
- Neurología
- Medicina del sueño
- Enfermedades neurodegenerativas
Sus antecedentes:
- La demencia con cuerpos de Lewy (DLB) se caracteriza por la neurodegeneración que afecta a las redes cerebrales.
- Los trastornos del sueño son una característica central de la DLB, afectando significativamente la calidad de vida del paciente.
Objetivo del estudio:
- Revisar el espectro de los trastornos del sueño en la demencia con cuerpos de Lewy.
- Discutir las estrategias terapéuticas actuales y potenciales para el manejo de los problemas de sueño en pacientes con DLB.
Principales métodos:
- Revisión de la literatura sobre los trastornos del sueño en la demencia con cuerpos de Lewy.
- Análisis de la fisiopatología que vincula la neurodegeneración con la interrupción del sueño en la DLB.
Principales resultados:
- El trastorno del comportamiento del sueño de movimiento rápido de los ojos (REM) y la hipersomnia son muy frecuentes en DLB.
- El insomnio, los trastornos respiratorios del sueño, los trastornos del movimiento nocturno y la disfunción urinaria también son comunes.
Conclusiones:
- Los trastornos del sueño son un sello distintivo de la demencia con cuerpos de Lewy, derivados de una neurodegeneración generalizada.
- Si bien existen tratamientos, son esenciales más ensayos clínicos para establecer una eficacia y seguridad óptimas para los pacientes con DLB.
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