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Updated: Sep 8, 2025

Combined Immunofluorescence and DNA FISH on 3D-preserved Interphase Nuclei to Study Changes in 3D Nuclear Organization
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La regulación transcripcional de la ligasa IV por un elemento regulador intrónico dirige el desarrollo del timocito

Matthew D Estrada1, Christopher J Gebhardt1, Mariam A Salem1,2

  • 1Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA.

Genes and immunity
|September 5, 2025
PubMed
Resumen

El estudio revela cómo se controla la transcripción del gen Ligasa IV (LIG4), particularmente en los linfocitos en desarrollo. Esta regulación es crucial para la reparación del ADN y el desarrollo adecuado de las células inmunes, destacando un nuevo mecanismo regulador.

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