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Skinspan: una hoja de ruta holística para extender la longevidad de la piel con intervenciones basadas en la
Elizabeth Kream1, Sabrina G Fabi1, Monica Boen1
1Cosmetic Laser Dermatology, San Diego, California, USA.
Journal of cosmetic dermatology
|September 6, 2025
Resumen
La introducción de "skinspan", un nuevo marco para la salud de la piel. Esta revisión explora intervenciones como la protección solar, los retinoides, los antioxidantes y las terapias emergentes para mantener la piel joven y promover la longevidad de la piel a largo plazo.
Área de la Ciencia:
- Dermatología y Medicina Estética
- Medicina Regenerativa y Gerología
Sus antecedentes:
- El enfoque en la investigación traslacional se ha desplazado de la vida útil a la salud.
- Se introduce el concepto de "skin span" para describir y orientar la salud y la apariencia de la piel a largo plazo.
Objetivo del estudio:
- Establecer "la extensión de la piel" como un marco para la salud de la piel a largo plazo.
- Revisar los factores moleculares del envejecimiento de la piel y las intervenciones basadas en la evidencia.
- Para sintetizar la evidencia en un algoritmo para expandir la extensión de la piel.
Principales métodos:
- Revisión exhaustiva de la literatura sobre las características moleculares del envejecimiento de la piel (inestabilidad genómica, disfunción mitocondrial, senescencia celular, disminución de la proteostasis).
- Evaluación de las intervenciones: modificaciones del estilo de vida, agentes farmacológicos y procedimientos estéticos.
- Categoría de las intervenciones basadas en la fuerza de la evidencia para aumentar la extensión de la piel.
Principales resultados:
- Las intervenciones proactivas son prometedoras para mitigar los mecanismos de envejecimiento de la piel.
- Estrategia de primera línea recomendada: protección solar, retinoides tópicos y antioxidantes.
- Segunda línea: dispositivos basados en láser y energía; tercera línea: terapias emergentes (células madre, sirtuinas, nicotinamida).
Conclusiones:
- El marco skinspan ofrece un enfoque holístico y basado en la evidencia para la longevidad de la piel.
- Promueve la prevención, la continuidad de la atención y la educación del paciente más allá de las intervenciones estéticas aisladas.
- Se necesitan ensayos controlados aleatorios adicionales para fortalecer la base de pruebas.
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