Video Experimental Relacionado

Updated: Sep 8, 2025

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
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Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission

Published on: August 16, 2018

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La unión al sustrato y al inhibidor del transportador humano de GABA 3

Hao Xu1, Yimin Zhang2, Qinru Bai3

  • 1Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China; Key Laboratory of Biomacromolecules (CAS), National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.

Structure (London, England : 1993)
|September 6, 2025
PubMed
Resumen

Los investigadores aclararon la estructura del transportador GABA 3 (GAT3), revelando cómo se une al GABA y al medicamento para la epilepsia SNAP-5114. Esto proporciona información para el desarrollo de nuevos tratamientos para la epilepsia dirigidos a GAT3.

Palabras clave:
El transportador de GABAEl GAT3SNAP-5114 y sus derivadosEstructura criogénica

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