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Bacteremia por Odoribacter splanchnicus: una condición rara asociada con enfermedades intestinales
Hiroshi Umemura1, Hirokazu Kobayashi2, Yumiko Tanimichi3
1Division of Laboratory Medicine, Department of Pathology and Microbiology, Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan; Division of Infection Control and Prevention, Nihon University Itabashi Hospital, Itabashi-ku, Tokyo, Japan.
Anaerobe
|September 6, 2025
Resumen
La bacteremia por Odoribacter splanchnicus es rara pero está en aumento. Este estudio identificó cinco nuevos casos, expandiendo los sitios de infección conocidos más allá del intestino y proporcionando datos cruciales de susceptibilidad antimicrobiana.
Área de la Ciencia:
- Microbiología médica
- Enfermedades infecciosas
- Bacteriología clínica
Sus antecedentes:
- Odoribacter splanchnicus es una bacteria anaeróbica que generalmente reside en el intestino humano.
- Las infecciones causadas por O. splanchnicus son poco frecuentes, con sólo unos pocos casos reportados previamente.
- Los hallazgos recientes sugieren un aumento potencial de la bacteremia por O. splanchnicus.
Objetivo del estudio:
- Identificar y caracterizar los casos recientes de bacteremia por Odoribacter splanchnicus.
- Investigar la presentación clínica y las fuentes de infección de O. splanchnicus bacteremia.
- Determinar los patrones de susceptibilidad antimicrobiana de los aislados de O. splanchnicus que causan bacteriemia.
Principales métodos:
- Búsqueda retrospectiva de un sistema de información de laboratorio desde 2014 hasta 2024.
- Análisis de los datos clínicos y de las fuentes de infección de los casos identificados.
- Prueba de sensibilidad antimicrobiana de los aislados de O. splanchnicus.
Principales resultados:
- Se identificaron cinco nuevos casos de bacteriemia por O. splanchnicus.
- Las infecciones se asociaron principalmente con problemas intestinales, pero un caso se relacionó con una úlcera de decúbito.
- O. splanchnicus mostró sensibilidad a los beta-lactamas y al metronidazol, con cierta resistencia a la clindamicina y una sensibilidad intermedia a la levofloxacina.
Conclusiones:
- La bacteremia de Odoribacter splanchnicus, aunque es rara, puede no ser diagnosticada adecuadamente.
- El espectro de infecciones causadas por O. splanchnicus puede ser más amplio de lo que se pensaba anteriormente.
- La vigilancia continua y la acumulación de casos son vitales para comprender la patogénesis de O. splanchnicus y orientar el tratamiento.
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