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Updated: Sep 8, 2025
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Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
Published on: October 15, 2019
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Factores biopsicosociales y ambientales que afectan las interacciones cerebro-intestino-microbioma en la obesidad
Riya Sood1, Lisa A Kilpatrick2, Laurie A Keefer3
1David Geffen School of Medicine, University of California, Los Angeles; University of Texas Medical Branch, John Sealy School of Medicine.
Resumen
Los determinantes sociales de la salud (SDOH) tienen un impacto significativo en el riesgo de obesidad al influir en el sistema cerebro-intestino-microbioma (BGM). Abordar el SDOH es crucial para el manejo personalizado de la obesidad y la mejora de los resultados de los pacientes.
Área de la Ciencia:
- Neurociencia y Salud Pública
- Investigación del microbioma
- Patogénesis de la obesidad
Sus antecedentes:
- La prevalencia de la obesidad está aumentando a pesar de los avances en la comprensión de sus causas.
- Los determinantes sociales de la salud (SDOH) son factores de riesgo clave para la obesidad.
- El SDOH incluye factores económicos, sociales y ambientales que afectan a la salud.
Objetivo del estudio:
- Revisar el vínculo entre la SDOH y la obesidad.
- Para explorar el papel del sistema cerebro-intestino-microbioma (BGM).
- Para entender cómo el SDOH influye en los comportamientos alimenticios y la obesidad a través de la BGM.
Principales métodos:
- Revisión sistemática de la literatura.
- Análisis de la contribución del SDOH al desarrollo y la gestión de la obesidad.
- Examen de los mecanismos de BGM en las relaciones SDOH-obesidad.
Principales resultados:
- El sistema BGM media el vínculo SDOH-obesidad a través de péptidos, marcadores inflamatorios y metabolitos.
- Los factores estresantes del entorno interrumpen el BGM, afectando a los microbios intestinales, el eje HPA y las redes de recompensa.
- La desregulación de la BGM impulsa el deseo de alimentos ricos en calorías.
Conclusiones:
- Reconocer el impacto de SDOH en BGM es vital para el tratamiento de la obesidad.
- Los enfoques personalizados y equitativos que tienen en cuenta el SDOH pueden mejorar los resultados.
- Abordar el SDOH mejora la adherencia al tratamiento y la calidad de vida de las personas con obesidad.
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