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Bone Disorders01:29

Bone Disorders

5.1K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
5.1K
Bone Remodeling01:40

Bone Remodeling

40.3K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
40.3K
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
3.9K
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

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The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
3.7K
What is the Skeletal System?01:02

What is the Skeletal System?

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Overview
56.8K
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

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The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
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Video Experimental Relacionado

Updated: Jan 17, 2026

Author Spotlight: Integrating Traditional Chinese Medicine with Modern Pharmacology and Genomics for Assessing Postmenopausal Osteoporosis in Mice
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Author Spotlight: Integrating Traditional Chinese Medicine with Modern Pharmacology and Genomics for Assessing Postmenopausal Osteoporosis in Mice

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La osteoporosis

Carrie Ye1, Peter Ebeling2, Gregory Kline3

  • 1Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada; Northern Alberta Osteoporosis Program, Alberta Health Service, Edmonton, AB, Canada.

Lancet (London, England)
|September 14, 2025
PubMed
Resumen
Este resumen es generado por máquina.

Las fracturas osteoporóticas son un problema de salud importante en las poblaciones que envejecen. Este seminario proporciona orientación clínica actualizada sobre el cribado de la osteoporosis, la evaluación del riesgo y los tratamientos efectivos, incluido el manejo seguro de los medicamentos.

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Área de la Ciencia:

  • Gerontología
  • La ortopedia
  • Farmacología

Sus antecedentes:

  • Las fracturas osteoporóticas representan una carga significativa para la salud de las personas mayores.
  • A pesar de las terapias disponibles, los tratamientos para la osteoporosis siguen siendo poco utilizados.
  • Se necesita un enfoque clínico actualizado para abordar este desafío.

Objetivo del estudio:

  • Presentar un enfoque actualizado y basado en la evidencia para la consulta de la osteoporosis para los médicos.
  • Proporcionar orientación pragmática sobre el manejo de la osteoporosis y la prevención de las fracturas.
  • Consolidar la evidencia actual y el dictamen de expertos para su aplicación clínica práctica.

Principales métodos:

  • Revisión de la evidencia publicada sobre el tratamiento de la osteoporosis.
  • Síntesis de opiniones de expertos en colaboración.
  • Centrarse en el cribado actualizado, la evaluación de riesgos y las intervenciones terapéuticas.

Principales resultados:

  • Discusión de nuevas pruebas sobre el cribado y la evaluación del riesgo de fracturas.
  • Orientaciones sobre las decisiones de intervención, incluidas las terapias nutricionales y farmacológicas.
  • Estrategias prácticas para el tratamiento de poblaciones complejas de pacientes y la gestión de la interrupción del tratamiento.

Conclusiones:

  • Un enfoque actualizado y basado en la evidencia puede optimizar el manejo de la osteoporosis.
  • El cribado eficaz, la evaluación de riesgos y las terapias adaptadas son cruciales para la prevención de fracturas.
  • Las estrategias de manejo seguro, incluida la interrupción de la medicación, son esenciales para la seguridad del paciente.