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La evaluación clínica de la miastenia gravis

Tarin A Europa1, Sui H Wong2, Jeannine M Heckmann3

  • 1Neurology Research Group, UCT Neuroscience Institute, University of Cape Town, Cape Town, South Africa.

International review of neurobiology
|October 16, 2025
PubMed

Se considera firmemente el diagnóstico de miastenia gravis (MG) en un paciente que presenta debilidad fatigable y en quien se demuestra la fatigabilidad muscular durante la exploración clínica. Este capítulo se dedicará a la anamnesis y al examen clínico de los pacientes con MG, y también abordaremos otros síndromes miasténicos y diagnósticos diferenciales. La mayoría de los pacientes experimentan primero síntomas oculares fatigables. Los síntomas pueden permanecer aislados en los ojos (MG ocular) o afectar posteriormente a los músculos limbicos, bulbares o respiratorios (MG generalizada). La exploración del paciente miasténico sirve para demostrar la fatigabilidad y distinguirla de la fatiga central inespecífica o de la falta de energía. Este capítulo presenta una discusión focalizada por parte de un neurooftalmólogo y neurólogos, basada principalmente en su experiencia clínica.

Palabras clave:
Fatiga centralFatigabilidadDebilidad fatigableMiastenia gravisMímicos de la miasteniaSíndromes miasténicos

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