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Updated: Jan 6, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

Published on: February 7, 2019

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Tipo de perezona enantioselectiva y catalítica [5 + 2] Cicloadición

Liangliang Yang1, Chaoshen Zhang1, Jianwei Sun1

  • 1Department of Chemistry and the Hong Kong Branch of Chinese National Engineering Research Centre for Tissue Restoration & Reconstruction, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR 999077, China.

Journal of the American Chemical Society
|October 17, 2025
PubMed
Resumen

Este estudio introduce la primera cicloadición catalítica enantioselectiva de tipo perezona [5 + 2]. Este nuevo método proporciona un acceso eficiente a los complejos biciclo[3.2.1]octanos y carbociclos utilizando un catalizador quiral de cuadramida.

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