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Updated: Jan 9, 2026

Transmembrane Domain Oligomerization Propensity determined by ToxR Assay
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Transmembrane Domain Oligomerization Propensity determined by ToxR Assay

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Perspectivas de la Dinámica Molecular sobre la Activación del Dominio Transmembrana de TAS1R2

Yongcheng Lu1,2, Xinyi Ma1,2, Ziyue Meng1,2

  • 1Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, Bouvé College of Health Sciences, Northeastern University, Boston, MA 02115, USA.

International journal of molecular sciences
|December 11, 2025
PubMed
Resumen

Los receptores del gusto dulce (STR) funcionan a través de heterodímeros TAS1R2/TAS1R3. Las simulaciones de dinámica molecular revelan cambios estructurales distintos inducidos por agonistas y antagonistas, descubriendo nuevas perspectivas sobre los mecanismos de activación de los receptores del gusto.

Palabras clave:
Receptor acoplado a proteína G (GPCR)simulaciones de MDcambios conformacionalesinteracciones proteína-ligandoactivación del receptorreceptor del gusto dulce

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