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Obesity

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The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...

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Influence of Emotional Factors on the Efficacy of Acupuncture Treatment for Overweight Complicated with Hyperlipidemia: A Retrospective Cohort Study

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Obesidad y Depresión: Una Relación Fisiopatotóxica

Francisco A Monsalve¹, Barbra Fernández-Tapia², Oscar C Arriagada¹

¹Department of Preclinical Sciences, Faculty of Medicine, Universidad Católica del Maule, Talca 3466706, Chile.

International journal of molecular sciences

|December 11, 2025

Resumen

Este resumen es generado por máquina.

La obesidad y el trastorno depresivo mayor comparten vías biológicas, incluidas alteraciones inflamatorias, neuroendocrinas, metabólicas y del eje intestino-cerebro. Comprender estas conexiones es clave para estrategias de tratamiento integradas.

Palabras clave:

eje HPA depresión inflamación disfunción metabólica eje microbiota-intestino-cerebro neuroinflamación obesidad

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Área de la Ciencia:

Neurociencia
Inmunología
Trastornos Metabólicos

Sus antecedentes:

La obesidad y el trastorno depresivo mayor (TDM) son enfermedades de prevalencia mundial con una incidencia creciente.
La evidencia epidemiológica y molecular sugiere una superposición significativa en su biología subyacente.

Objetivo del estudio:

Revisar y sintetizar la evidencia actual sobre la epidemiología y fisiopatología compartidas de la obesidad y el TDM.
Enfatizar los mecanismos convergentes, incluidos los ejes inflamatorio, neuroendocrino, metabólico, genético y del eje intestino-cerebro.

Principales métodos:

Revisión narrativa de la investigación epidemiológica y molecular existente.
Síntesis de la evidencia sobre las vías bidireccionales que vinculan la obesidad y la depresión.

Principales resultados:

Las vías compartidas incluyen inflamación crónica de bajo grado, desregulación del eje hipotalámico-pituitario-adrenal (HPA), déficits en la señalización metabólica y neurotrófica, neurotoxicidad derivada de lípidos y alteraciones del eje intestino-cerebro.
Estos mecanismos contribuyen a la neuroinflamación y la desregulación del estado de ánimo en personas con obesidad.

Conclusiones:

Se necesitan estrategias de manejo integradas para abordar la interacción entre la obesidad y el TDM.
La investigación futura debe centrarse en biomarcadores compartidos e intervenciones personalizadas utilizando enfoques multiómicos y de medicina de sistemas.