Video Experimental Relacionado
Updated: Jan 8, 2026
The Use of Gas Chromatography to Analyze Compositional Changes of Fatty Acids in Rat Liver Tissue during Pregnancy
Published on: March 13, 2014
Determinación y predicción de la trayectoria bioquímica de la enfermedad en la colestasis intrahepática del embarazo:
Nicholas J Williamson1, Jenna Sajous1, Tim Im Korevaar2
1Department of Women and Children's Health, King's College London, London, UK.
Background:
The severity of intrahepatic cholestasis of pregnancy (ICP) reflects peak maternal bile acid (BA) concentration. However, the course of the disease is unclear.
Methods:
Longitudinal observational cohort study of individuals with ICP. Serial BA and alanine aminotransferase (ALT) trajectories were determined according to starting severity. Multiple logistic regression identified variables predictive of subsequent disease severity, validated using data from a randomised controlled trial.
Results:
Although highly variable, BA concentrations increased across gestation (p > 0.001). Normal ALT concentration at diagnosis predicted concurrent non-severe disease (negative predictive value 94.2% (91.6-96.1%)). Gestational age and BA concentration at diagnosis somewhat predicted later moderate or severe disease (BA ≥ 40 µmol/L: ROCAUC 0.64 (0.58-0.69); BA ≥ 100 µmol/L: ROCAUC 0.68 (0.62-0.73)), similarly in the validation cohort (ROCAUC 0.70 (0.65-0.76) and 0.69 (0.63-0.76), respectively).
Conclusion:
An earlier gestation and higher BA concentration at diagnosis increase the likelihood of more severe disease; however robust prediction is limited.
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