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Factor de transcripción c-Maf: un punto de control que programa la autoinmunidad

Na Liu¹, Jin Zhang², Pingping Wang³

¹Center of Medical Research, Weifang People's Hospital, Shandong Second Medical University, Weifang, Shandong, China.

Frontiers in immunology

|December 12, 2025

Abstract:

The transcription factor c-Maf, a member of the Maf family characterized by its basic domain and b-Zip DNA-binding motif, is a pivotal regulator of immune cells development and function. It governs immune cells growth, differentiation, function, and immune responses. This review explores the mechanistic role of c-Maf and its associated signaling networks in modulating autoimmunity and inflammation. We highlight its dual function as an immune checkpoint that suppresses pathological inflammation while promoting protective immunity, underscoring its therapeutic potential in autoimmune diseases.

Palabras clave:

enfermedades autoinmunes autoinmunidad c-Maf punto de control inmunitario inflamación

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