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Modificación tardía de péptidos con etiqueta de salicilaldehído mejora la afinidad por el modulador esencial del
Mattia Mason1, Kaliroi Peqini2, Federico Uggeri1
1Università degli Studi di Milano, Dipartimento di Chimica 20133 Milano Italy alberto.dalcorso@unimi.it.
RSC chemical biology
|December 12, 2025
Resumen
Los investigadores desarrollaron un nuevo método de funcionalización de péptidos utilizando etiquetas de salicilaldehído (SA) para ligandos covalentes reversibles. Esta técnica mejoró la afinidad de unión a NEMO, una proteína clave en las vías de inflamación, ofreciendo aplicaciones terapéuticas potenciales.
Sus antecedentes:
- El factor nuclear kappa-light-chain-enhancer de las células B activadas (NFκB) es un factor de transcripción crucial en las respuestas inflamatorias.
- NEMO (modulador esencial de NF-κB) es una proteína clave en la vía de señalización de NFκB, lo que la convierte en un objetivo terapéutico.
- Los ligandos basados en péptidos ofrecen especificidad, pero a menudo requieren optimización para mejorar la afinidad de unión y la estabilidad.
Conclusiones:
- La funcionalización tardía de péptidos con etiquetas SA es una estrategia versátil para crear ligandos potentes.
- El enfoque de etiquetado SA mejora la afinidad de los péptidos dirigidos a proteínas como NEMO.
- Este método es prometedor para el desarrollo de nuevas terapias dirigidas a las vías inflamatorias mediadas por NFκB.
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