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Technical Modification of the Terminal Ureter During Total Transperitoneal Laparoscopic Nephroureterectomy for Upper Urinary Tract Urothelial Carcinoma
Published on: November 22, 2019
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Patología de los tumores del tracto urinario superior: subtipos histológicos, genética, pruebas de biomarcadores
Eva Compérat1, Shahrokh Shariat2, Olivier Cussenot2
1Department of Pathology, Medical University Vienna, Vienna, Austria.
Histopathology
|December 12, 2025
Resumen
El carcinoma urotelial del tracto superior (UTUC) está ganando atención en la uro-oncología. Esta revisión guía la selección de biomarcadores para la medicina personalizada y una mejor comprensión de los mecanismos moleculares del UTUC.
Área de la Ciencia:
- Uro-oncología
- Patología molecular
Sus antecedentes:
- El carcinoma urotelial del tracto superior (UTUC) es cada vez más reconocido en la uro-oncología.
- El diagnóstico puede ser complejo debido a subtipos raros de UC y otras morfologías de carcinoma.
Objetivo del estudio:
- Revisar y guiar la selección de biomarcadores para el UTUC.
- Discutir la caracterización molecular del UTUC para la medicina personalizada.
Principales métodos:
- Revisión de la literatura actual sobre biomarcadores de UTUC.
- Análisis de las evaluaciones de pruebas a nivel de proteína (inmunohistoquímica) y moleculares.
Principales resultados:
- Identificación de biomarcadores clave para el diagnóstico y manejo del UTUC.
- Caracterización de alteraciones moleculares comunes y poco frecuentes en el UTUC.
Conclusiones:
- La comprensión de los mecanismos moleculares del UTUC es crucial para el descubrimiento de biomarcadores.
- Los enfoques de medicina personalizada requieren información molecular detallada para opciones terapéuticas novedosas.
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