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Author Spotlight: In Vitro Co-Culture Model for Studying Microglia-Neuronal Interactions in Disease Conditions
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Cultivos co-simbrados de organoides humanos y cortes cerebrales de ratón para estudiar la función microglial

Vasiliki Panagiotakopoulou1, Marc Welzer2, Olmo Ruiz Ormaechea1

  • 1Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, 72076 Tübingen, Germany; German Center for Neurodegenerative Diseases (DZNE), 72076 Tübingen, Germany.

Cell reports
|December 12, 2025
PubMed
Resumen

Este estudio introduce un novedoso modelo cerebral quimérico que utiliza organoides humanos y cortes cerebrales de ratón para madurar la microglía humana. Este sistema in vitro avanzado permite el estudio a largo plazo de la microglía en un entorno similar al cerebro humano.

Palabras clave:
neurocienciainvestigación de células madreorganoides cerebralesmodelo in vitro quiméricomicroglía humanaxenotrasplante

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