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Desvelando la Diversidad Global de Patescibacteriota e Interacciones Funcionales con Microbios Huésped
Yanhan Ji1, Xu Liu1, Shuai Zhao2
1Key Laboratory of Agricultural and Environmental Microbiology, Ministry of Agriculture and Rural Affairs, Department of Microbiology, College of Life Sciences, Nanjing Agricultural University, Nanjing, Jiangsu, 210014, China.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|December 12, 2025
Resumen
La radiación de filos candidatos (CPR), o Patescibacteriota, son bacterias diminutas con una distribución global desconocida. Este estudio revela sus diversos roles en el apoyo al metabolismo del huésped a través de funciones complementarias, destacando su importancia ecológica.
Área de la Ciencia:
- Microbiología; Genómica; Ecología
Sus antecedentes:
- Patescibacteriota (Candidate Phyla Radiation, CPR) son bacterias ultrapequeñas y ubicuas con un estilo de vida epibiótico.
- Su distribución global e interacciones funcionales con los huéspedes son en gran parte desconocidas.
- Comprender el papel ecológico de CPR es crucial para la dinámica de las redes microbianas.
Objetivo del estudio:
- Determinar la distribución global y la diversidad taxonómica de Patescibacteriota.
- Investigar las interacciones funcionales y las sinergias metabólicas entre Patescibacteriota y bacterias asociadas al huésped.
- Identificar marcadores filogenéticos confiables para la detección de CPR en datos metagenómicos.
Principales métodos:
- Se utilizaron recursos genómicos integrales de Patescibacteriota y conjuntos de datos metagenómicos globales de múltiples hábitats.
- Se empleó la proteína ribosomal S3 (rpS3) como marcador filogenético para una recuperación precisa de la diversidad a partir de metagenomas de lectura corta.
- Se realizó análisis de redes y cribado funcional a nivel de genoma para descubrir patrones de co-ocurrencia e interacciones metabólicas.
Principales resultados:
- Se identificó una amplia diversidad taxonómica y una heterogeneidad comunitaria significativa de Patescibacteriota en ocho ecosistemas diversos.
- Se revelaron patrones de co-ocurrencia específicos del hábitat entre Patescibacteriota y otras bacterias, lo que indica posibles sinergias funcionales.
- Se descubrieron enzimas codificadas por Patescibacteriota (NirK, NorB) que pueden mitigar el estrés del huésped por nitrito y óxido nítrico.
Conclusiones:
- Patescibacteriota posee una diversidad subestimada y desempeña un papel vital en el apoyo al metabolismo del huésped a través de funciones bioquímicas complementarias.
- Este estudio proporciona nuevas perspectivas sobre la importancia ecológica y las adaptaciones evolutivas de Patescibacteriota en los ecosistemas globales.
- rpS3 se valida como un marcador confiable para recuperar la diversidad de CPR de datos metagenómicos.
Palabras clave:
CPRepisimbiontescomplementación metabólicadesintoxicación de nitritopatescibacteriotaproteína ribosomal S3Más Videos Relacionados
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