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Videos de Conceptos Relacionados

Diffusion01:12

Diffusion

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Diffusion is the passive movement of substances down their concentration gradients—requiring no expenditure of cellular energy. Substances, such as molecules or ions, diffuse from an area of high concentration to an area of low concentration in the cytosol or across membranes. Eventually, the concentration will even out, with the substance moving randomly but causing no net change in concentration. Such a state is called dynamic equilibrium, which is essential for maintaining overall...
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Passive Diffusion: Overview and Kinetics01:17

Passive Diffusion: Overview and Kinetics

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Passive diffusion is a critical process that allows small lipophilic drugs to cross the cell membrane along a concentration gradient. This mechanism's efficiency depends on four primary factors: the membrane's surface area, the drug's lipid-water partition coefficient, the concentration gradient, and the membrane's thickness.
When administered orally, drugs establish a substantial concentration gradient between the gastrointestinal (GI) lumen and the bloodstream, expediting...
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Facilitated Diffusion01:16

Facilitated Diffusion

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The plasma membrane, a critical structure in cellular biology, houses an array of transporters, or carrier proteins, interspersed within its lipid bilayer. These proteins play a crucial role in solute transport through facilitated diffusion, a form of passive diffusion that uses transporters to move the molecules across the membrane.
In this process, substrates such as organic compounds and ions interact with a transporter on one side, triggering conformational changes in proteins that enable...
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Theories of Dissolution: Diffusion Layer Model01:15

Theories of Dissolution: Diffusion Layer Model

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Dissolution, the process by which drug particles dissolve in a solvent, is explained by the diffusion layer model, a theoretical framework that simulates the absorption of oral drugs and allows us to analyze experimental data.
This process starts with a thin layer, saturated with the drug, forming at the interface between the solid and liquid. The solute then diffuses from this layer into the main solution. The Noyes-Whitney equation suggests that the rate of dissolution relies on the diffusion...
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Mechanisms of Drug Absorption: Paracellular, Transcellular, and Vesicular Transport01:23

Mechanisms of Drug Absorption: Paracellular, Transcellular, and Vesicular Transport

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Drugs need to permeate cell membranes to reach their target sites after administration. Orally administered drugs must transcend intestinal epithelial membrane barriers to infiltrate the systemic circulation. Drugs with a molecular weight of less than 500 Daltons diffuse through gaps between neighboring cells, called paracellular pathways.
However, most drugs use the transcellular route, traversing directly through the cell membranes via two mechanisms: passive and active transport. Passive...
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Theories of Dissolution: The Danckwerts' Model and Interfacial Barrier Model01:09

Theories of Dissolution: The Danckwerts' Model and Interfacial Barrier Model

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Various dissolution theories provide insight into the factors that influence the dissolution rate. Danckwerts' Model suggests that turbulence, rather than a stagnant layer, characterizes the dissolution medium at the solid-liquid interface. In this model, the agitated solvent contains macroscopic packets that move to the interface via eddy currents, facilitating the absorption and delivery of the drug to the bulk solution. The regular replenishment of solvent packets maintains the...
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Speciation and Bioavailability Measurements of Environmental Plutonium Using Diffusion in Thin Films
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Speciation and Bioavailability Measurements of Environmental Plutonium Using Diffusion in Thin Films

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Ingeniería subsuperficial mediada por difusión atómica

Xiaolin Tai1, Yanan Zhou2, Shilong Xu3

  • 1Hefei National Research Center for Physical Sciences at the Microscale, Key Laboratory of Precision and Intelligent Chemistry, School of Chemistry and Materials Science, University of Science and Technology of China, Hefei, Anhui, PR China.

Nature communications
|December 13, 2025
PubMed
Resumen
Este resumen es generado por máquina.

Se logró un control preciso de las capas atómicas subsuperficiales en catalizadores de platino mediante la ingeniería de las vías de difusión atómica. Esta ingeniería subsuperficial mejora la actividad y durabilidad catalíticas para celdas de combustible.

Palabras clave:
ingeniería subsuperficialdifusión atómicacatalizadores de platinoceldas de combustiblecatálisis heterogénea

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Área de la Ciencia:

  • Ciencia de Materiales
  • Ciencia de la Catálisis
  • Ciencia de Superficies

Sus antecedentes:

  • La disposición atómica subsuperficial influye críticamente en el rendimiento catalítico al gobernar las reacciones superficiales.
  • El control preciso de las estructuras subsuperficiales es un desafío debido a las complejas interacciones metal-adsorbato y la accesibilidad limitada.

Objetivo del estudio:

  • Lograr un control preciso de las capas atómicas subsuperficiales en compuestos intermetálicos a base de platino.
  • Desarrollar una estrategia racional para el diseño de catalizadores mediante la comprensión de los sitios activos subsuperficiales.

Principales métodos:

  • Construcción in situ de vías de difusión atómica para la colocación dirigida de átomos heterometálicos.
  • Ingeniería subsuperficial de precisión atómica para crear estructuras L1₀-PtFe@PtMsub.
  • Reorganización atómica inducida termodinámicamente, regida por la minimización de la energía superficial y la segregación inducida por adsorbato.

Principales resultados:

  • Se sintetizaron con éxito L1₀-PtFe@PtMsub (Msub = Ru, Rh, Pd, Ag) con disposiciones atómicas subsuperficiales controladas.
  • L1₀-PtFe@PtPdsub demostró la estabilización simultánea de efectos de ligando y tensión, superando las limitaciones de la piel de Pt.
  • El catalizador exhibió alta actividad y durabilidad en celdas de combustible de membrana de intercambio de protones.

Conclusiones:

  • La ingeniería subsuperficial de precisión atómica ofrece una estrategia racional para diseñar catalizadores avanzados.
  • La comprensión y el control de los sitios activos subsuperficiales son cruciales para optimizar la catálisis heterogénea.
  • El catalizador desarrollado L1₀-PtFe@PtPdsub/C muestra una aplicación práctica prometedora en celdas de combustible.