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Prevotella copri promueve el dorado de la grasa blanca y mejora la adiposidad

Shuang Liu¹, Haifang Li², Rui Li³

¹College of Animal Science and Technology, Shandong Agricultural University, Tai'an, People's Republic of China.

Nature communications

|December 13, 2025

Resumen

La abundancia de Prevotella copri es menor en la obesidad. Esta bacteria intestinal y su metabolito succinato promueven el dorado del tejido adiposo blanco, ofreciendo estrategias potenciales contra la obesidad.

Sus antecedentes:

El simbionte de la microbiota intestinal Prevotella es poco comprendido en cuanto a su papel en la salud del huésped.
Las funciones específicas de Prevotella copri en la regulación metabólica no están claras.

Conclusiones:

Prevotella copri juega un papel en la promoción del dorado de iWAT.
El succinato actúa como un metabolito clave derivado de P. copri que influye en el tejido adiposo.
Las vías IL-6-STAT3 y FOXM1 están involucradas en el dorado de iWAT mediado por P. copri.
Los hallazgos sugieren posibles estrategias terapéuticas dirigidas a P. copri o succinato para el manejo de la obesidad.

Palabras clave:

Prevotella copri obesidad tejido adiposo blanco dorado del tejido adiposo succinato microbiota intestinal

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