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Manufacture and Drug Delivery Applications of Silk Nanoparticles

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Enfoque emergente de administración de fármacos utilizando nanomateriales para el tratamiento del cáncer de

Zhuorong Miao¹, Xiaoyan Xiong², Jiahong Gao¹

¹Shenzhen Maternity and Child Healthcare Hospital, Women and Children's Medical Center, Southern Medical University, Shenzhen, Guangdong Province, China.

Frontiers in medical technology

|December 15, 2025

Abstract:

Endometrial cancer, accounting for over 90% of uterine malignancies, has experienced a significant global rise in incidence and mortality. Conventional therapies face limitations including fertility compromise, systemic toxicity, drug resistance, and poor outcomes in advanced/recurrent cases. Considering the unique physical and chemical properties of nanomaterials, the emerging drug delivery approaches based on nanomaterials are regarded as a promising pathway for enhanced therapeutic efficiency to combat endometrial cancer. Herein, this mini-review discusses emerging drug delivery approaches to overcome current treatment challenges. We classify common therapeutic nanomaterials into polymer-based nanocarriers, quantum dots, liposomes, and exosomes, analyzing their synthesis, mechanisms, and preclinical efficacy. Finally, scientific challenges and future perspectives for ongoing research in this field are presented.

Palabras clave:

administración de fármacos cáncer de endometrio tratamiento de preservación de la fertilidad nanomateriales nanoplataforma

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