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Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments

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PitNET tissue deconvolution: rastreo de residuos de tejido normal y dinámica inmunitaria

Mattia Dalle Nogare¹, Serena Avallone^1,2, Luna Picello¹

¹Department of Biology, University of Padova, Padova, Italy.

Frontiers in endocrinology

|December 15, 2025

Resumen

Este estudio presenta un nuevo método para analizar la composición celular de tumores hipofisarios utilizando datos de secuenciación de ARN. Identifica con precisión células hipofisarias normales residuales en muestras de tumores, mejorando la comprensión de los tumores neuroendocrinos hipofisarios.

Palabras clave:

ARN total secuenciación (RNA-seq)heterogeneidad celular métodos de deconvolución tumores neuroendocrinos hipofisarios (PitNETs)ARN de una sola célula secuenciación (snRNA-seq)

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