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Uso de metotrexato en la artritis idiopática juvenil y su impacto en el desarrollo de la placa de crecimiento: un

Shreyansh Ahirwar¹, Prashant Panale², Chetan Shokeen³

¹Department of Dentistry, District Hospital, Vidisha, Madhya Pradesh, India.

|December 15, 2025

Abstract:

Juvenile Idiopathic Arthritis (JIA) is a chronic inflammatory disease that can disrupt normal skeletal growth in children. Methotrexate (MTX) is widely used as a disease-modifying therapy in JIA, has uncertain effects on the developing growth plate and bone elongation. Hence, we enrolled 40 children with JIA, dividing them equally into MTX-exposed and non-MTX groups and evaluated growth plate morphology (via imaging), growth velocity (using height-for-age Z-scores) and biochemical markers (IGF-1, ALP, Vitamin D) over 12 months. The MTX group showed significantly reduced growth velocity (ΔZ = 0.31 vs. 0.58, p < 0.01), more epiphyseal irregularities on MRI (35% vs. 5%) and lower IGF-1 and ALP levels compared to controls. Although no severe skeletal defects were found, these findings suggest MTX may subtly affect growth, highlighting the need for careful longitudinal monitoring in treated children.

Palabras clave:

IGF-1 artritis idiopática juvenil RM placa de crecimiento velocidad de crecimiento metotrexato reumatología pediátrica

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