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Neutrophil Isolation and Analysis to Determine their Role in Lymphoma Cell Sensitivity to Therapeutic Agents
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Relación neutrófilos-linfocitos: un marcador de apoyo potencial para infecciones del torrente sanguíneo de
Peijuan Li1, Jiulin Zhang2, Kun Chen3
1General Practice Ward/International Medical Center Ward, General Practice Medical Center, West China Hospital, Sichuan University, Chengdu, China.
Background:
Exploring the value of the neutrophil/lymphocyte ratio (NLR) as a potential supportive marker in community-acquired bloodstream infection in elderly patients.
Methods:
By reviewing the data of inpatients in Xuanwu Hospital of Capital Medical University from January 2012 to December 2021, a total of 58 elderly patients with community-acquired bloodstream infection and 174 inpatients without infection during the same period, matched for age, sex, and concomitant diseases, were included. Clinical data were collected and analyzed statistically.
Results:
There were no significant differences in age, sex, and concomitant diseases between the infected and non-infected groups. Multivariate regression analysis showed that only increased NLR among leukocyte indexes was a risk factor for bloodstream infections. The sensitivity, specificity, and area under the curve (AUC) of increased NLR to support the diagnosis of community-acquired bloodstream infections in the elderly were 0.72, 0.99, and 0.95; the optimal cut-off value is 8.0.
Conclusion:
The increase in NLR was superior to the rise of traditional white blood cell and neutrophil counts. Thus, NLR can be used as an indication for the early diagnosis of community-acquired bloodstream infection in the elderly. The optimal cutoff value of NLR for supporting the diagnosis of community-acquired bloodstream infections in elderly patients was determined to be 8.0. When NLR exceeds this threshold (> 8.0), it serves as a clinical alert for community physicians, indicating a significantly elevated probability of elderly patients developing community-acquired bloodstream infections.
