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Evaluación de guías de luz líquidas en sistemas de espectroscopía de correlación difusa

Yuanzhe Zhang¹, Mingliang Pan¹, Chenxu Li¹

¹University of Strathclyde, Department of Biomedical Engineering, Glasgow, UK.

Biomedical optics express

|December 15, 2025

Resumen

El reemplazo de las fibras convencionales por guías de luz líquidas en la espectroscopía de correlación difusa (DCS) mejora significativamente la calidad de la señal. Este avance mejora la precisión del monitoreo del flujo sanguíneo sin comprometer los límites de seguridad.

Área de la Ciencia:

Óptica biomédica
Medición fisiológica

Sus antecedentes:

La espectroscopía de correlación difusa (DCS) es un método óptico no invasivo clave para evaluar el flujo sanguíneo tisular.
La DCS precisa requiere una alta relación señal-ruido (SNR), a menudo limitada por las restricciones de seguridad tisular en la irradiancia óptica.

Objetivo del estudio:

Investigar el uso de guías de luz líquidas (LLG) como alternativa a las fibras multimodo (MMF) para la iluminación DCS.
Mejorar la sensibilidad de la estimación del flujo sanguíneo y la SNR de DCS dentro de los límites de seguridad.

Principales métodos:

Comparación experimental de sistemas de iluminación LLG y MMF en DCS.
Evaluación del rendimiento de fotones, uniformidad de la iluminación y SNR bajo restricciones de irradiancia idénticas.

Principales resultados:

La iluminación LLG proporcionó un perfil más uniforme y un mayor rendimiento de fotones que la MMF.
El sistema DCS basado en LLG logró un aumento de aproximadamente tres veces en la SNR en comparación con el sistema MMF.
Se logró una SNR mejorada sin exceder los límites máximos de exposición permitidos.

Conclusiones:

Las guías de luz líquidas mejoran eficazmente la sensibilidad y la SNR de DCS al mejorar la eficiencia y uniformidad de la entrega de luz.
La iluminación LLG ofrece una estrategia viable para mejorar el monitoreo no invasivo del flujo sanguíneo en aplicaciones biomédicas.
Esta técnica permite mediciones de flujo sanguíneo más precisas y sensibles dentro de las directrices de seguridad establecidas.

Palabras clave:

Espectroscopía de correlación difusa Guías de luz líquidas Óptica biomédica Flujo sanguíneo Relación señal-ruido

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