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Updated: Jan 8, 2026

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Exposición al alcohol durante el embarazo y su impacto en el neurodesarrollo fetal: un análisis bibliométrico y de

Paulo Fernando Santos Mendes¹, Julia Karine Miranda Rodrigues², Pedro Anibal Cardoso Barros²

¹Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Belém, PA, Brazil.

Naunyn-Schmiedeberg's archives of pharmacology

|December 15, 2025

Abstract:

Alcohol consumption per capita is increasing, particularly among women of reproductive age. When consumed during pregnancy, it can induce spontaneous abortion and changes in neurodevelopment as it is a compound with high teratogenic potential. Studies have been performed to describe the effects of maternal-fetal alcohol exposure. This review aimed to identify and map knowledge about alcohol exposure during pregnancy and its effects on fetal neurodevelopment, based on an analysis of the 100 most cited articles. To achieve this goal, we performed a comprehensive search of the Web of Science Core Collection database, employing a search strategy that included terms related to alcohol consumption during pregnancy. The evaluated studies reported that there are no safe doses of alcohol exposure during pregnancy or by women trying to get pregnant, that the effects of alcohol intake are proportional to the dose and modality of exposure, that these damages occur in different brain regions, and that these effects are related to the period of neurodevelopment.

Palabras clave:

Alcohol Consumo de alcohol Síndrome alcohólico fetal Neurodesarrollo Embarazo Exposición prenatal

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Teratogenicity

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...