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Updated: May 2, 2026
Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy
Published on: August 5, 2014
Validación y Datos Normativos de una Entrevista Autobiográfica Modificada para Uso en Pacientes Taiwaneses con
Wei-Yang Chen1, Ta-Cheng Chen1, Pai-Yi Chiu2
1Department of Neurology, Changhua Christian Hospital, No. 135, Nanxiao St., Changhua City, Changhua 500, Taiwan.
Objective:
Autobiographical memory (AM) refers to the recollection of events in an individual's life. AM deficits have been associated with brain disorders, such as temporal lobe epilepsy (TLE). Researchers have developed interview protocols to assess AM deficits. We aimed to validate a modified version of the Autobiographical Interview (mAI) among Taiwanese patients with TLE.
Methods:
A normative reference sample of 100 healthy individuals was established to model age- and education-adjusted performance. From this group, 38 individuals were matched to TLE patients to validate discriminative ability.
Results:
The mAI demonstrated high interrater reliability. Retrieval of episodic AM from childhood was associated with linguistic ability. Retrieval of episodic AM from adolescence involved both arbitrary and meaningful associations. Retrieval of episodic AM from recent life was not dependent on arbitrary associations. Age was negatively associated with episodic AM retrieval, whereas educational level was positively associated.
Conclusions:
TLE patients displayed deficits in episodic AM retrieval from adolescence while AM retrieval from childhood and recent life was preserved. These results support the validity of the mAI as a tool for assessing AM deficits in TLE patients.
