Video Experimental Relacionado

Updated: Jan 8, 2026

Selection of Aptamers for Amyloid β-Protein, the Causative Agent of Alzheimer's Disease

Selection of Aptamers for Amyloid β-Protein, the Causative Agent of Alzheimer's Disease

Published on: May 13, 2010

AmyloPick: Un nuevo método de selección de características y evaluación adecuada para la predicción de hexapéptidos

Katarzyna Stapor¹, Aleksandra Lewandowska¹, Piotr Fabian¹

¹Department of Applied Informatics, Silesian University of Technology, Gliwice, Poland.

|December 16, 2025

Resumen

Desarrollamos AmyloPick, un nuevo modelo de cuatro características para predecir la agregación de proteínas en hexapéptidos e identificar regiones propensas a la agregación (APR). Esta herramienta ofrece una mayor precisión e interpretabilidad que los métodos existentes, lo que ayuda en la investigación de enfermedades neurodegenerativas.

Palabras clave:

APR SVM agregación amiloide agrupamiento evaluación estadística

Más Videos Relacionados

A Tailored HPLC Purification Protocol That Yields High-purity Amyloid Beta 42 and Amyloid Beta 40 Peptides, Capable of Oligomer Formation

A Tailored HPLC Purification Protocol That Yields High-purity Amyloid Beta 42 and Amyloid Beta 40 Peptides, Capable of Oligomer Formation

Published on: March 27, 2017

A11-positive β-amyloid Oligomer Preparation and Assessment Using Dot Blotting Analysis

A11-positive β-amyloid Oligomer Preparation and Assessment Using Dot Blotting Analysis

Published on: May 22, 2018

Videos de Conceptos Relacionados

Amyloid Fibrils

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins. Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils.
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining,...