Desarrollos recientes en PROTACs dirigidos a quinasas dependientes de ciclina (CDK) en terapia contra el cáncer

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Updated: Jan 8, 2026

Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay

Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay

Published on: May 3, 2018

Arijit Nandi¹, Anwesha Das², M Rhia L Stone¹

¹Centre for Superbug Solutions, Institute for Molecular Bioscience, The University of Queensland, Brisbane 4067, Queensland Australia.

ACS medicinal chemistry letters

|December 17, 2025

Abstract:

CDK-based PROTAC therapeutics are a promising new approach in oncology. In this microperspective, we summarize the landscape of anticancer PROTAC development targeting the CDK family as of 2024. We discuss the applications and outcomes of computational screening, alternative degradation strategies, different linkers, SAR, and the use of new E3 ligases. Finally, we explore the potential to enhance pharmacokinetic properties through the incorporation of different linkers in heterobifunctional molecules.

Palabras clave:

quimera heterobifuncional serina-treonina quinasa degradación de proteínas dirigida complejo ternario

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