Video Experimental Relacionado

Updated: Jan 8, 2026

Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood

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Plan de anticoagulación individualizado impulsado por farmacocinética para atletas pediátricos con anticoagulantes

Devin Donnelly¹, Riten Kumar^1,2

¹Dana Farber/Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts, USA.

Pediatric blood & cancer

|December 17, 2025

Abstract:

Children on anticoagulation have traditionally been discouraged from participating in contact and collision sports due to a perceived bleeding risk. The predictable pharmacokinetics of direct oral anticoagulants permit more individualized management. At Boston Children's Hospital, pharmacokinetic (PK) data were used to develop individualized anticoagulation plans for five athletes on anticoagulation who wished to participate in contact or collision sports. Median (range) duration of follow-up for the cohort was 27 (1-42) months. During this period, two patients sustained four sports-related injuries during anticoagulation interruption, but no clinically significant bleeding or recurrent/progressive thrombosis was observed. All patients safely resumed anticoagulation post-injury.

Palabras clave:

Terapia de anticoagulación Hematología/oncología pediátrica Farmacocinética

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