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Red de WNT10A-SMOC2-LRP4 afecta el desarrollo del diente permanente a través de una posible interacción diente-hueso
Yiqi Chen1,2, Xuechun Li1,2, Siyuan Ma1,2
1Center of Stomatology and Research Center of Oral and Maxillofacial Development and Regeneration, Xiangya Hospital, Central South University, 87 Xiangya Road, City, Changsha, Province, 410008, Hunan, China.
BMC oral health
|December 18, 2025
Resumen
La agenesia dental no sindrómica implica la pérdida de dientes permanentes. Este caso relaciona variaciones en los genes WNT10A, SMOC2 y LRP4 con la agenesia dental, sugiriendo que las células óseas mandibulares influyen en el desarrollo dental a través de la señalización FGF.
Área de la Ciencia:
- Genética
- Biología del Desarrollo
- Salud Bucodental
Sus antecedentes:
- La agenesia dental no sindrómica (ADNS) se caracteriza por la pérdida de dientes permanentes.
- No se comprende bien la influencia del entorno mandibular en la ADNS.
- Este estudio investiga variaciones genéticas simultáneas en la ADNS.
Objetivo del estudio:
- Explorar el impacto potencial del entorno mandibular en la agenesia dental.
- Analizar las variaciones genéticas en WNT10A, SMOC2 y LRP4 en un paciente con ADNS.
- Investigar las vías de señalización involucradas en el desarrollo dental.
Principales métodos:
- Examen clínico y secuenciación del exoma completo de un paciente con ADNS.
- Secuenciación de Sanger para variaciones genéticas específicas.
- Reanálisis de conjuntos de datos de secuenciación de ARN de célula única y tinción de inmunofluorescencia.
Principales resultados:
- El paciente presentó dientes temporales retenidos, ausencia de dientes permanentes y densidad ósea mandibular anormal.
- Se identificaron variaciones novedosas en LRP4 y variaciones conocidas en SMOC2 y WNT10A.
- Las células óseas positivas para LRP4 envían señales a las células de la pulpa dental positivas para WNT10A/SMOC2 a través de FGF.
Conclusiones:
- Las variaciones simultáneas en SMOC2 y una variación novedosa de LRP4 se asocian con la agenesia dental y el desarrollo óseo.
- Las células del hueso alveolar positivas para LRP4 pueden regular el desarrollo dental a través de la señalización FGF.
- Esta vía de señalización influye en WNT10A y SMOC2 en las células de la pulpa dental.
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