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Isquemia Mesentérica Aguda como Complicación Grave Asociada a Tirzepatida: Informe de Caso y Alerta de Seguridad

Shani Brooks¹, Samraiz Nafees², Khaled Abdi²

¹Emergency Medicine, York and Scarborough Teaching Hospitals NHS Foundation Trust, Scarborough, GBR.

|December 19, 2025

Abstract:

Tirzepatide is a glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist used in the management of type 2 diabetes mellitus. We report a case of acute mesenteric ischemia in a patient following treatment with tirzepatide, highlighting a rare but serious adverse event potentially related to its effects on gastrointestinal motility and vascular perfusion. This case emphasizes the necessity for careful patient selection and close clinical monitoring, especially given the increasing use of this medication outside of formal supervision.

Palabras clave:

isquemia mesentérica aguda complicaciones gastrointestinales agonista del receptor glp-1 tirzepatida uso de medicamentos sin supervisión medicamento para perder peso

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