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SIRT1: Una estrategia potencial para combatir la COVID-19 grave

Hajar Shokri-Afra¹, Fatemeh Saber Jeyvan², Zeinab Barartabar³

¹Gut and Liver Research Center, Non-Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran, mazums.ac.ir.

BioMed research international

|December 19, 2025

Resumen

La proteína Sirtuina 1 (SIRT1) mejora las respuestas antivirales y mitiga la COVID-19 grave al regular la señalización inmune y la entrada viral. Los activadores naturales de SIRT1 como el resveratrol ofrecen potencial terapéutico contra el SARS-CoV-2.

Conclusiones:

SIRT1 es un componente crítico de la defensa humana contra el SARS-CoV-2.
La modulación de la actividad de SIRT1, potencialmente con activadores naturales como el resveratrol, muestra promesa terapéutica para la COVID-19.
La focalización de SIRT1 podría conducir a estrategias novedosas para el manejo de infecciones virales como la COVID-19.

Palabras clave:

COVID-19 SARS-CoV-2 tormenta de citoquinas inflamación vías de señalización sirtuina 1

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