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Videos de Conceptos Relacionados

Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
3.8K
Bone Cells and Tissue01:30

Bone Cells and Tissue

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Bones contain a relatively small number of cells entrenched in a matrix of organic and inorganic components. Although bone cells compose only a small amount of the bone volume, they are crucial to its function. Four types of cells are found within the bone tissue— osteoblasts, osteocytes, osteogenic cells, and osteoclasts.
Osteoblasts and Osteocytes
The osteoblast is the bone cell responsible for forming new bone tissue. It is found in the growing portions of bone, including the...
7.9K
Bone Remodeling01:40

Bone Remodeling

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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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The Bone Matrix01:18

The Bone Matrix

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Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in...
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Bone Formation by Intramembranous Ossification01:29

Bone Formation by Intramembranous Ossification

10.0K
Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into ...
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Bone Formation by Endochondral Ossification01:24

Bone Formation by Endochondral Ossification

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Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...
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Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

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Phosphatidylserine exposure and annexin A5 weaken the actin cortex in osteoclast fusion.

The Journal of cell biology·2025
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Elevated surface La promotes hyperfusion and contributes to impaired resorption in osteopetrosis.

bioRxiv : the preprint server for biology·2025
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PHOSPHATIDYLSERINE EXPOSURE AND EXTRACELLULAR ANNEXIN A5 WEAKEN THE ACTIN CORTEX IN OSTEOCLAST FUSION.

bioRxiv : the preprint server for biology·2025
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Cell-cell fusion: To lose one life and begin another.

BioEssays : news and reviews in molecular, cellular and developmental biology·2024
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Formation of multinucleated osteoclasts depends on an oxidized species of cell surface-associated La protein.

eLife·2024
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Cell surface-bound La protein regulates the cell fusion stage of osteoclastogenesis.

Nature communications·2023

Video Experimental Relacionado

Updated: Jan 8, 2026

Osteoclast Derivation from Mouse Bone Marrow
06:17

Osteoclast Derivation from Mouse Bone Marrow

Published on: November 6, 2014

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Fusión celular en la osteoclastogénesis

Leonid V Chernomordik1, Kamran Melikov1

  • 1Section on Membrane Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, 20892, U.S.A.

Biochemical Society transactions
|December 19, 2025
PubMed
Resumen

La fusión de osteoclastos crea células multinucleadas esenciales para la remodelación ósea. Comprender las proteínas que regulan este proceso es clave para tratar enfermedades óseas.

Palabras clave:
Anexina A5Sincitina 1vía de fusiónfusión de osteoclastosfosfatidilserina

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Differentiation of Functional Osteoclasts from Human Peripheral Blood CD14+ Monocytes
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Last Updated: Jan 8, 2026

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Área de la Ciencia:

  • Biología Celular
  • Biología Ósea
  • Bioquímica

Sus antecedentes:

  • Los osteoclastos multinucleados son cruciales para la remodelación ósea a través de la fusión de precursores mononucleados.
  • La actividad de reabsorción ósea de los osteoclastos aumenta con el tamaño, lo que requiere un control estricto sobre la iniciación y terminación de la fusión.

Objetivo del estudio:

  • Revisar los mecanismos y las proteínas involucradas en la fusión de osteoclastos.
  • Destacar las similitudes y diferencias entre la fusión de osteoclastos y otros procesos de fusión célula-célula.
  • Identificar las lagunas de conocimiento en la maquinaria proteica de la fusión de osteoclastos.

Principales métodos:

  • Revisión de la literatura sobre mecanismos de fusión celular.
  • Análisis comparativo de la fusión de osteoclastos con la formación de células de músculo esquelético.
  • Discusión de proteínas y vías reguladoras.

Principales resultados:

  • La fusión de osteoclastos comparte similitudes mecanicistas con otros eventos de fusión célula-célula.
  • La maquinaria proteica específica que impulsa los reordenamientos de la membrana de los osteoclastos sigue siendo poco comprendida.
  • La regulación de la fusión de osteoclastos es fundamental para mantener la homeostasis ósea.

Conclusiones:

  • Comprender los mecanismos de fusión de osteoclastos es vital para la salud ósea.
  • La investigación adicional sobre las proteínas de fusión de osteoclastos podría conducir a nuevos tratamientos para trastornos esqueléticos.
  • La focalización de la fusión de osteoclastos ofrece estrategias terapéuticas potenciales para enfermedades que involucran la reabsorción ósea anormal.