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Videos de Conceptos Relacionados

Proteomics01:33

Proteomics

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A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
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Protein Networks02:26

Protein Networks

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An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
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Ribosome Profiling02:24

Ribosome Profiling

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Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique...
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Diversity of Antigen Receptors01:28

Diversity of Antigen Receptors

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Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
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Protein-protein Interfaces02:04

Protein-protein Interfaces

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Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
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Protein Complexes with Interchangeable Parts01:57

Protein Complexes with Interchangeable Parts

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Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order...
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Updated: Jan 8, 2026

Mass Spectrometry-Based Proteomics Analyses Using the OpenProt Database to Unveil Novel Proteins Translated from Non-Canonical Open Reading Frames
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Descifrando el Proteoma Críptico entre Antígenos y Nuevas Proteínas Funcionales

Emma G Bawden1, Sebastian Amigorena1, Yago A Arribas1

  • 1Inserm U932 Immunity and Cancer, Institut Curie, PSL University, Paris, 75005, France.

European journal of immunology
|December 19, 2025
PubMed
Resumen
Este resumen es generado por máquina.

La complejidad del proteoma humano aumenta con proteínas crípticas del genoma no codificante. Estas proteínas ofrecen una fuente de antígenos para la vigilancia inmunitaria y amplían la diversidad de proteínas funcionales para la evolución.

Palabras clave:
DRiPspresentación de antígenosproteoma crípticoinmunopeptidómicaperfilado de ribosomas

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Área de la Ciencia:

  • Genómica
  • Proteómica
  • Inmunología

Sus antecedentes:

  • El genoma humano contiene una vasta región no codificante, previamente considerada no funcional.
  • Descubrimientos recientes muestran la traducción de proteínas crípticas a partir de ADN no codificante, expandiendo la complejidad del proteoma.
  • Estas proteínas a menudo se expresan en niveles bajos, se degradan rápidamente y se presentan en MHC-I.

Objetivo del estudio:

  • Proponer un modelo que explique el papel de las proteínas crípticas en la evolución del proteoma humano y la vigilancia inmunitaria.
  • Investigar cómo las proteínas crípticas contribuyen a la diversidad de proteínas funcionales.
  • Comprender la fuente de antígenos para la inmunovigilancia.

Principales métodos:

  • Modelado teórico de la traducción de proteínas crípticas y sus implicaciones evolutivas.
  • Análisis de la expresión de proteínas, la degradación y las vías de presentación en MHC-I.
  • Revisión de la literatura existente sobre la traducción del genoma no codificante y la inmunología.

Principales resultados:

  • Las proteínas crípticas aumentan la diversidad de proteínas funcionales disponibles para la selección evolutiva.
  • Un subconjunto de proteínas crípticas puede ser estable y funcional, integrándose en el proteoma.
  • Las proteínas crípticas sirven como fuente de antígenos para la vigilancia del sistema inmunitario.

Conclusiones:

  • La traducción de proteínas crípticas es un factor significativo en la expansión del proteoma y la evolución.
  • Las proteínas crípticas desempeñan un doble papel: expandir la diversidad funcional y proporcionar antígenos para la inmunovigilancia.
  • Este proceso resalta la interacción dinámica entre el genoma no codificante, la evolución de las proteínas y la respuesta inmunitaria.