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Updated: Jan 8, 2026

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La serotonina modula la plasticidad del linaje en el cáncer de próstata neuroendocrino mediante la reprogramación

Yiyi Ji1, Cheng-Wei Ju2, Lei Chen3

  • 1University of Chicago Chicago United States.

Cancer discovery
|December 19, 2025
PubMed
Resumen

La progresión del cáncer de próstata neuroendocrino (CPN) está impulsada por una vía de serotonina interna. La inhibición de la síntesis de serotonina con carbidopa reduce eficazmente el crecimiento tumoral y mejora la supervivencia en modelos de CPN.

Palabras clave:
cáncer de próstata neuroendocrinoserotoninaplasticidad del linajereprogramación epigenéticacarbidopainhibición de DDChistona serotonilaciónH3K4me3Q5señalización del receptor de andrógenosoncologíabiología molecularinvestigación del cáncer

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