Modelo de computación cerebral individualizado y estable informado por patrones de coactividad espaciotemporal

Accurate simulation of the brain's intrinsic dynamic activity is essential for understanding human cognition and behavior and developing personalized brain disease therapies. Traditional neurodynamics models depend on structural connectivity to explain the emergence of functional connectivity (FC). However, achieving high-fidelity simulations at the individual level remains challenging, as the models fail to fully capture the brain information. To address these challenges, we introduce the Stable Individualized Brain Computing Model (SI-BCM), a data-driven reverse engineering framework designed to infer spatiotemporal co-activity patterns from fMRI data for simulating whole-brain activity. This model captures the dynamic interactions between brain regions by integrating spatiotemporal dimensional information to extract a stable and shared connectivity pattern, representing the intrinsic functional collaboration pattern of the brain. This connectivity pattern is then used as the core connection weight in the dynamical system. Additionally, the model has a new cost function based on the Phase-Space Association matrix (PSA), enhancing its ability to capture brain activity dynamics. This combination enables the SI-BCM to improve simulation accuracy at the individual level compared to existing models, achieving a correlation coefficient between simulated and empirical FC of 0.87. The SI-BCM also showed enhanced robustness and reliability, and effectively captured brain properties. We found the model sensitively reflected changes in cognitive function, thereby providing valuable insights into the underlying neural mechanisms. Furthermore, the application of SI-BCM in the brain modeling of Alzheimer's disease (AD) patients substantiated the hypothesis that AD pathogenesis may be due to excessive neuronal excitation. This work establishes a new paradigm for brain network modeling by prioritizing the inference of stable dynamics features from activity data, providing a powerful tool for understanding brain function and pathophysiology.