Video Experimental Relacionado

Updated: Jan 8, 2026

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Un bucle de retroalimentación positivo KAT7-lncPVT1 promueve la carcinogénesis del cáncer de pulmón y la resistencia

Yanwei Lu¹, Xiaoyan Chen¹, Luanluan Huang¹

¹Cancer Center, Department of Radiation Oncology, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China.

International journal of biological macromolecules

|December 19, 2025

Abstract:

Lung cancer is one of the most life-threatening malignant tumors. The progression of tumors driven by chemo-radiotherapy resistance is the primary determinant of poor clinical outcomes, highlighting the crucial need for mechanistic insights into resistance pathways. In this study, we uncover that Lysine Acetyltransferase 7 (KAT7) overexpression not only promotes non-small cell lung cancer (NSCLC) cell proliferation in vitro and tumor growth in vivo but also confers resistance to chemotherapy and radiotherapy, which has been previously underexplored in NSCLC. Mechanistically, KAT7 forms a positive feedback loop with long non-coding RNA PVT1 (lncPVT1) and regulates the H3K14ac/HDGF axis and PI3K/AKT signaling pathway. This study aims to elucidate the molecular mechanisms by which the mutual regulation of KAT7, lncPVT1, and HDGF drives the proliferation and chemo-radiotherapy resistance of NSCLC.

Palabras clave:

HDGF KAT7 CPNM PI3K/AKT lncPVT1

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