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Primera confirmación del complejo Mycobacterium tuberculosis de la Irlanda medieval mediante análisis de aDNA:

Eileen M Murphy¹, G Michael Taylor², Tom A Mendum²

¹Archaeology and Palaeoecology, School of Natural and Built Environment, Queen's University Belfast, Belfast, BT7 1NN, Northern Ireland, UK.

Tuberculosis (Edinburgh, Scotland)

|December 19, 2025

Abstract:

Eight burials from the multi-period rural settlement site of Ranelagh near Roscommon town, Ireland, with palaeopathological lesions suggestive of skeletal tuberculosis or brucellosis were examined by ancient DNA (aDNA) testing. Tuberculosis infection (MTB complex DNA) was confirmed in five individuals - an 11th-13th CE adolescent female (14.5-17.5 years), two young adults females (18-35 years, 7th-10th CE), one adolescent of unknown sex and one middle-aged adult (35-50 years, medieval in date). In the latter case, the differential diagnosis included brucellosis due to the presence of small multifocal lytic lesions in the lower spinal vertebrae. However, this individual and all cases tested negative for Brucella species DNA. In two positive cases, lineage 4 (Euro-American) Mycobacterium tuberculosis DNA was identified in extracts obtained from tooth pulp cavities. These are the first archaeological individuals from Ireland to have had tuberculosis infection confirmed through aDNA analysis.

Palabras clave:

ADN antiguo PCR Paleopatología Ranelagh Tuberculosis

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