Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Aging01:26

Aging

566
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
566
Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

4.5K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.5K
Biological Clocks and Seasonal Responses02:45

Biological Clocks and Seasonal Responses

41.4K
The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.
41.4K
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

3.1K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
3.1K
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

175
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
175
Replication in Eukaryotes01:29

Replication in Eukaryotes

17.0K
In eukaryotic cells, DNA replication is highly conserved and tightly regulated. Multiple linear chromosomes must be duplicated with high fidelity before cell division, so there are many proteins that fulfill specialized roles in the replication process. Replication occurs in three phases: initiation, elongation, and termination, and ends with two complete sets of chromosomes in the nucleus.
Many Proteins Orchestrate Replication at the Origin
Eukaryotic replication follows many of the same...
17.0K

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Dietary bioactive compounds and inflammaging: Pro-inflammatory triggers and geroprotective countermeasures.

Ageing research reviews·2026
Same author

Natural modulators of enhancer of zeste homolog 2 (EZH2): potential epigenetic regulators of aging-associated pathways.

Biogerontology·2026
Same author

Somatic mutations impose an entropic upper bound on human lifespan.

npj aging·2026
Same author

Foundations of Gerophysics.

Aging·2026
Same author

Upskilling in Healthy Longevity Medicine and Its Association With Physicians' Implementation Intent and Self-Reported Clinical Confidence: Cross-Sectional Observational Study.

JMIR medical education·2026
Same author

Blood biochemical and gut microbiotic neural network models forecasting human biological age.

Aging·2026

Video Experimental Relacionado

Updated: Jan 8, 2026

Quantifying Yeast Chronological Life Span by Outgrowth of Aged Cells
12:24

Quantifying Yeast Chronological Life Span by Outgrowth of Aged Cells

Published on: May 6, 2009

17.2K

¿Realmente necesitamos relojes de envejecimiento?

Dmitrii Kriukov1,2, Evgeniy Efimov3,4, Mikhail S Gelfand3

  • 1Skolkovo Institute of Science and Technology, Moscow, Russia. kriukov@airi.net.

npj aging
|December 19, 2025
PubMed
Resumen

Los relojes de envejecimiento estiman la edad biológica pero enfrentan desafíos en la definición, validación e incertidumbre. Su valor práctico requiere una justificación explícita sobre los métodos establecidos de predicción de la salud.

Más Videos Relacionados

Preparing an Isotopically Pure 229Th Ion Beam for Studies of 229mTh
10:42

Preparing an Isotopically Pure 229Th Ion Beam for Studies of 229mTh

Published on: May 3, 2019

7.2K
Author Spotlight: Automated Lifespan Monitoring – Discovering Aging Dynamics with the Lifespan Machine
08:53

Author Spotlight: Automated Lifespan Monitoring – Discovering Aging Dynamics with the Lifespan Machine

Published on: January 26, 2024

1.6K

Videos de Experimentos Relacionados

Last Updated: Jan 8, 2026

Quantifying Yeast Chronological Life Span by Outgrowth of Aged Cells
12:24

Quantifying Yeast Chronological Life Span by Outgrowth of Aged Cells

Published on: May 6, 2009

17.2K
Preparing an Isotopically Pure 229Th Ion Beam for Studies of 229mTh
10:42

Preparing an Isotopically Pure 229Th Ion Beam for Studies of 229mTh

Published on: May 3, 2019

7.2K
Author Spotlight: Automated Lifespan Monitoring – Discovering Aging Dynamics with the Lifespan Machine
08:53

Author Spotlight: Automated Lifespan Monitoring – Discovering Aging Dynamics with the Lifespan Machine

Published on: January 26, 2024

1.6K

Área de la Ciencia:

  • Investigación biomédica
  • Aplicaciones de aprendizaje automático
  • Gerontología

Sus antecedentes:

  • Los relojes de envejecimiento son modelos de aprendizaje automático que estiman la edad biológica para evaluar la salud.
  • Su utilidad clínica es debatida debido a limitaciones inherentes.

Objetivo del estudio:

  • Evaluar críticamente el valor práctico de los relojes de envejecimiento.
  • Comparar los relojes de envejecimiento con las herramientas establecidas de evaluación de la salud.
  • Identificar áreas de mejora en la metodología de los relojes de envejecimiento.

Principales métodos:

  • Análisis comparativo de los relojes de envejecimiento.
  • Revisión de estudios de validación clínica.
  • Evaluación comparativa con puntuaciones de riesgo de expertos y predictores de resultados directos.

Principales resultados:

  • Los relojes de envejecimiento sufren de definiciones abstractas y validación clínica inconsistente.
  • La incertidumbre de la predicción a menudo se ignora, lo que limita la información práctica.
  • Los métodos establecidos pueden ofrecer un poder predictivo superior o comparable.

Conclusiones:

  • Los investigadores deben justificar explícitamente la ventaja de los relojes de envejecimiento sobre las alternativas existentes.
  • El enfoque debe estar en mejorar la transparencia, validación y cuantificación de la incertidumbre de los relojes.
  • Garantizar información práctica es crucial para el avance de la tecnología de los relojes de envejecimiento.