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Asociación entre la puntuación de depleción de magnesio y la hipertensión: perspectivas de un estudio a gran escala
Yunzhen Lei1, Jiaying Diao1, Ming Xu1
1Department of Cardiovascular Medicine, Hospital of Zunyi Medical University (The First Peoples Hospital of Zunyi), Zunyi, Guizhou Province, China.
Biological trace element research
|December 19, 2025
Resumen
Las puntuaciones más altas de depleción de magnesio (MDS) se asocian con un mayor riesgo de hipertensión. El análisis integrador revela que las vías genéticas en la regulación vascular y el estrés oxidativo pueden subyacer a esta asociación, ofreciendo nuevas perspectivas sobre el magnesio.
Área de la Ciencia:
- Salud Cardiovascular
- Epidemiología Nutricional
- Bioinformática
Sus antecedentes:
- El magnesio es crucial para la salud cardiovascular.
- La puntuación de depleción de magnesio (MDS) evalúa el estado del magnesio.
- Existen datos limitados sobre la puntuación MDS y la hipertensión en grandes poblaciones.
Objetivo del estudio:
- Examinar la asociación entre la puntuación MDS y el riesgo de hipertensión.
- Investigar los posibles mecanismos moleculares utilizando bioinformática.
- Explorar la relación dosis-respuesta y la mediación por factores metabólicos.
Principales métodos:
- Análisis de datos de encuestas transversales basadas en la población.
- Regresión logística multivariable y análisis de spline cúbico restringido (RCS).
- Bioinformática basada en genes (GO, KEGG, Reactome) y análisis de mediación.
Principales resultados:
- La puntuación MDS más alta se asoció de manera significativa e independiente con un mayor riesgo de hipertensión.
- Se observó una asociación no lineal; el riesgo aumentó drásticamente cuando la puntuación MDS > 1,59.
- Se identificaron 1193 genes superpuestos relacionados con la regulación vascular, el estrés oxidativo y las vías de señalización.
Conclusiones:
- La depleción de magnesio está fuertemente relacionada con el riesgo de hipertensión.
- Los mecanismos potenciales implican remodelación vascular, inflamación y alteración de la señalización del óxido nítrico.
- El análisis integrador proporciona información mecanicista sobre el estado del magnesio y la hipertensión.
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