Video Experimental Relacionado
Updated: Jan 8, 2026
Translational Orthotopic Models of Glioblastoma Multiforme
Published on: February 17, 2023
Diferenciación de la recurrencia tumoral y la pseudoprogresión en gliomas posoperatorios mediante la técnica de
Peiquan Liu1, Yujie Chen1, Xudong Ai2
1Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Objective:
To assess whether the pCASL technique and its radiomics features can enhance the differentiation between tumor recurrence (TR) and pseudoprogression (PsP) in postoperative glioma patients.
Methods:
A retrospective study of 120 postoperative glioma patients (WHO Grade 2-4) from Tongji Hospital, Wuhan, was conducted. MRI data, including T1WI, T2WI, T2FLAIR, contrast-enhanced T1WI, and pCASL, were analyzed. Final diagnoses of TR or PsP were confirmed through pathology or follow-up. Among the patients, 65 had recurrence, and 55 had PsP. Process the pCASL images to generate the CBF parameter map, then perform N4 bias correction and Z- score standardization to obtain the standardized CBF parameter map for group analysis. The lesion areas were outlined, and mean values for ROI were calculated. Statistical analysis included the Mann-Whitney U test and ROC curve analysis. Radiomics features were extracted from the CBF maps. These features were then further selected and divided into training and testing sets. Machine learning models, including Support Vector Machine (SVM), logistic regression, random forest, and Gaussian Naive Bayes, were developed and subsequently validated.
Results:
The Mann-Whitney U test showed a significant difference in mean CBF values between TR and PsP groups (p < 0.001). ROC analysis revealed an AUC of 0.879 (95% CI: 0.817-0.941), sensitivity of 0.846, specificity of 0.836, PPV of 0.859, and NPV of 0.821. After feature selection, seven radiomics features were retained. SVM yielded the best performance with an AUC of 0.971, sensitivity of 0.950, specificity of 0.813, PPV of 0.864, and NPV of 0.929.
Conclusion:
The pCASL technique, combined with radiomics features, effectively differentiates TR from PsP in postoperative glioma patients. The pCASL provides reliable diagnostic information, with radiomics further improving classification accuracy. The SVM model demonstrated the best performance, highlighting the potential of combining pCASL and radiomics for accurate, non-invasive differentiation of TR and PsP. This approach could enhance clinical decision-making and patient management.
