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Immunometabolic Circuits in Infection for Advancing Host Directed Therapies
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Macrófagos sintéticos bioingenierizados para funciones de células inmunitarias en la terapia celular de enfermedades

Shweta Khandibharad1, Shailza Singh1,2

  • 1Systems Medicine Laboratory, BRIC-National Centre for Cell Science, Pune, India.

FEBS letters
|December 20, 2025
PubMed
Resumen

Este estudio presenta un método de biología sintética para tratar la leishmaniasis cutánea (LC). Reprograma macrófagos utilizando un circuito genético inducible para expresar péptidos diseñados por IA, mejorando la eliminación de parásitos y la respuesta inmunitaria.

Palabras clave:
nanogel TAC6estrategia de transferencia adoptivacélulas modificadascircuito sintético

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